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0B4GT2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameB4GALT2
DescriptionBeta-1,4-galactosyltransferase 2 (ec 2.4.1.-) (beta-1,4-galtase 2) (beta4gal-t2) (b4gal-t2) (udp-galactose:beta-n-acetylglucosamine beta- 1,4-galactosyltransferase 2) (udp-gal:beta-glcnac beta-1,4- galactosyltransferase 2) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008378 galactosyltransferase activity (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This is a family of galactosyltransferases from a wide range of metazoa with three related galactosyltransferase activities; all three of which are possessed by one sequence in some cases. The three functions are N-acetyllactosamine synthase (); beta-N-acetylglucosaminyl-glycopeptide beta-1.-galactosyltransferase (); and lactose synthase (). Note that N-acetyllactosamine synthase is a component of lactose synthase along with alpha-lactalbumin.n the absence of alpha-lactalbumin N-acetyllactosamine synthase is used.
  IPR003859:Metazoa galactosyltransferase
IPR003859:Galactosyl_T_2 
Evalue:-196.200653076172 
Location:97-366
SequencesProtein: B4GT2_HUMAN (372 aa)
mRNA: NM_003780
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK00704
  Level 3 annotation:
    lactose synthase
  Level 2 annotation:
    Galactose metabolism
K00708
  Level 3 annotation:
    beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
  Level 2 annotation:
    N-Glycan biosynthesis
    Keratan sulfate biosynthesis
K00723
  Level 3 annotation:
    N-acetyllactosamine synthase
  Level 2 annotation:
    Other enzymes
K07967
  Level 3 annotation:
    beta-1,4-galactosyltransferase 2
  Level 2 annotation:
    Blood group glycolipid biosynthesis - neo-lactoseries
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 107 residues, 44217452-44217770Exon2: 123 residues, 44219367-44219732Exon3: 80 residues, 44219947-44220183Exon4: 65 residues, 44223123-44223314Exon5: 43 residues, 44223536-44223659Exon6: 37 residues, 44223775-44223880Exon7: 292 residues, 44228556-44229426Exon8: 2 residues, -Jump to B4GT2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2511 44217452-44229426 ~-12K 1299(B4GALT2)(+)Loci: 3798 44234742-44255584 ~-21K 1302(SLC6A9)(-)Loci: 2512 44451711-44458938 ~-7K 1306(DMAP1)(+)Loci: 2510 43888424-43943725 ~-55K 1275(JMJD2A)(+)Link out to UCSC