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0ATX7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameATXN7
DescriptionAtaxin-7 (spinocerebellar ataxia type 7 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0005515 protein binding (IPI)
0006997 nuclear organization and biogenesis (TAS)
0007601 visual perception (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK . This domain is also found in Ataxin-7. human protein which in its polyglutamine expanded pathological form.s responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7) .
  IPR013243:SCA7
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007087:Zinc finger, C2H2-type
IPR013243:SCA7 
Evalue:-44.9208183288574 
Location:317-397IPR007087:ZnF_C2H2 
Evalue:1.39794000867204 
Location:148-170
SequencesProtein: ATX7_HUMAN (892 aa)
mRNA: AF032105 NM_000333
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 148 residues, 63825272-63825715Exon2: 35 residues, 63859114-63859213Exon3: 114 residues, 63873303-63873639Exon4: 25 residues, 63873872-63873941Exon5: 37 residues, 63913094-63913199Exon6: 86 residues, 63940630-63940883Exon7: 88 residues, 63942901-63943161Exon8: 29 residues, 63943654-63943737Exon9: 90 residues, 63948774-63949040Exon10: 68 residues, 63950891-63951090Exon11: 42 residues, 63951453-63951575Exon12: 328 residues, 63956220-63957199Exon13: 402 residues, 63960165-63961366Exon14: 2 residues, -Jump to ATX7_HUMANExon1: 148 residues, 63825272-63825715Exon2: 35 residues, 63859114-63859213Exon3: 114 residues, 63873303-63873639Exon4: 25 residues, 63873872-63873941Exon5: 37 residues, 63913094-63913199Exon6: 86 residues, 63940630-63940883Exon7: 88 residues, 63942901-63943161Exon8: 29 residues, 63943654-63943737Exon9: 90 residues, 63948774-63949040Exon10: 68 residues, 63950891-63951090Exon11: 42 residues, 63951453-63951575Exon12: 373 residues, 63956220-63957333Exon13: 2 residues, -Jump to ATX7_HUMAN  
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