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0ATPO_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameATP5O
DescriptionAtp synthase o subunit, mitochondrial precursor (ec 3.6.3.14) (oligomycin sensitivity conferral protein) (oscp).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005753 proton-transporting ATP synthase complex (s... (TAS)
0005215 transporter activity (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.F-ATPases (also known as F1F0-ATPase.r H(+)-transporting two-sector ATPase) () are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha.eta.amma.elta.psilon).hile the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C).ine in mitochondria (A-G.6.8). Both the F1 and F0 complexes are rotary motors that are coupled back-to-back. In the F1 complex.he central gamma subunit forms the rotor inside the cylinder made of the alpha(3)beta(3) subunits.hile in the F0 complex.he ring-shaped C subunits forms the rotor. The two rotors rotate in opposite directions.ut the F0 rotor is usually stronger.sing the force from the proton gradient to push the F1 rotor in reverse in order to drive ATP synthesis . These ATPases can also work in reverse to hydrolyse ATP to create a proton gradient. This family represents subunits called delta in bacterial and chloroplast ATPase.r OSCP (oligomycin sensitivity conferral protein) in mitochondrial ATPase (note that in mitochondria there is a different delta subunit.. The OSCP/delta subunit appears to be part of the peripheral stalk that holds the F1 complex alpha3beta3 catalytic core stationary against the torque of the rotating central stalk.nd links subunit A of the F0 complex with the F1 complex. In mitochondria.he peripheral stalk consists of OSCP.s well as F0 components F6. and D. In bacteria and chloroplasts the peripheral stalks have different subunit compositions: delta and two copies of F0 component B (bacteria).r delta and F0 components B and B (chloroplasts) .More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR000711:ATPase, F1 complex, OSCP/delta subunit
IPR000711:OSCP 
Evalue:-74.8860549926758 
Location:37-209
SequencesProtein: ATPO_HUMAN (213 aa)
mRNA: NM_001697
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK02137
  Level 3 annotation:
    F-type H+-transporting ATPase oligomycin sensitivity conferral protein
  Level 2 annotation:
    ATP synthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 63 residues, 34197627-34197813Exon2: 31 residues, 34198108-34198195Exon3: 39 residues, 34201514-34201627Exon4: 45 residues, 34203255-34203385Exon5: 39 residues, 34206462-34206573Exon6: 19 residues, 34208623-34208674Exon7: 44 residues, 34209901-34210028Exon8: 2 residues, -Jump to ATPO_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4549 34197627-34210028 ~-12K 23791(ATP5O)(-)Loci: 3287 34367692-34437198 ~-70K 23793(MRPS6)(+)Loci: 3286 33936653-34183479 ~-247K 23790(ITSN1)(+)Link out to UCSC