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0ATPG_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameATP5C1
DescriptionAtp synthase gamma chain, mitochondrial precursor (ec 3.6.3.14).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005753 proton-transporting ATP synthase complex (s... (TAS)
0005215 transporter activity (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.F-ATPases (also known as F1F0-ATPase.r H(+)-transporting two-sector ATPase) () are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha.eta.amma.elta.psilon).hile the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C).ine in mitochondria (A-G.6.8). Both the F1 and F0 complexes are rotary motors that are coupled back-to-back. In the F1 complex.he central gamma subunit forms the rotor inside the cylinder made of the alpha(3)beta(3) subunits.hile in the F0 complex.he ring-shaped C subunits forms the rotor. The two rotors rotate in opposite directions.ut the F0 rotor is usually stronger.sing the force from the proton gradient to push the F1 rotor in reverse in order to drive ATP synthesis . These ATPases can also work in reverse to hydrolyse ATP to create a proton gradient.The ATPase F1 complex gamma subunit forms the central shaft that connects the F0 rotary motor to the F1 catalytic core. The gamma subunit functions as a rotary motor inside the cylinder formed by the alpha(3)beta(3) subunits in the F1 complex . The best-conserved region of the gamma subunit is its C-terminus.hich seems to be essential for assembly and catalysis.More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR000131:ATPase, F1 complex, gamma subunit
IPR000131:ATP-synt 
Evalue:-135.88606262207 
Location:26-297
SequencesProtein: ATPG_HUMAN (298 aa)
mRNA: NM_001001973 NM_005174
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK02136
  Level 3 annotation:
    F-type H+-transporting ATPase gamma chain
  Level 2 annotation:
    ATP synthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 45 residues, 7870098-7870232Exon2: 13 residues, 7878089-7878124Exon3: 46 residues, 7879015-7879147Exon4: 70 residues, 7880958-7881163Exon5: 50 residues, 7881740-7881884Exon6: 23 residues, 7881995-7882060Exon7: 54 residues, 7884238-7884394Exon8: 34 residues, 7884726-7884823Exon9: 14 residues, 7888942-7888979Exon10: 46 residues, 7889627-7889761Exon11: 2 residues, -Jump to ATPG_HUMANExon1: 45 residues, 7870098-7870232Exon2: 13 residues, 7878089-7878124Exon3: 46 residues, 7879015-7879147Exon4: 70 residues, 7880958-7881163Exon5: 50 residues, 7881740-7881884Exon6: 23 residues, 7881995-7882060Exon7: 54 residues, 7884238-7884394Exon8: 34 residues, 7884726-7884823Exon9: 46 residues, 7889627-7889761Exon10: 2 residues, -Jump to ATPG_HUMAN  
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