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0ATPF2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameATPAF2
DescriptionAtp synthase mitochondrial f1 complex assembly factor 2, mitochondrial precursor (atp12 homolog).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Mitochondrial F1-ATPase is an oligomeric enzyme composed of five distinct subunit polypeptides. The alpha and beta subunits make up the bulk of protein mass of F1. In Saccharomyces cerevisiae both subunits are synthesised as precursors with N-terminal targeting signals that are removed upon translocation of the proteins to the matrix compartment . These proteins include examples from eukaryotes and bacteria and may have chaperone activity.eing involved in F1 ATPase complex assembly.
  IPR011419:ATP12 ATPase
IPR011419:ATP12 
Evalue:-78.7447280883789 
Location:33-169
SequencesProtein: ATPF2_HUMAN (289 aa)
mRNA: AY203943 NM_145691
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK07556
  Level 3 annotation:
    ATP synthase mitochondrial F1 complex assembly factor 2
  Level 2 annotation:
    Other energy metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 223 residues, 17862058-17862725Exon2: 40 residues, 17865161-17865277Exon3: 39 residues, 17865783-17865896Exon4: 29 residues, 17868662-17868743Exon5: 34 residues, 17870357-17870455Exon6: 50 residues, 17872270-17872416Exon7: 17 residues, 17872653-17872698Exon8: 97 residues, 17882919-17883205Exon9: 2 residues, -Jump to ATPF2_HUMANExon1: 140 residues, 17862306-17862725Exon2: 40 residues, 17865161-17865277Exon3: 39 residues, 17865783-17865896Exon4: 29 residues, 17868662-17868743Exon5: 34 residues, 17870357-17870455Exon6: 50 residues, 17872270-17872416Exon7: 17 residues, 17872653-17872698Exon8: 94 residues, 17882919-17883196Exon9: 2 residues, -Jump to ATPF2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4272 17862058-17883205 ~-21K 15261(ATPAF2)(-)Loci: 4271 17656110-17681050 ~-25K 15251(SREBF1)(-)Link out to UCSC