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0ATP9B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameATP9B
DescriptionPotential phospholipid-transporting atpase iib (ec 3.6.3.1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (NAS)
0015247 aminophospholipid transporter activity (NAS)
0005524 ATP binding (NAS)
0019829 cation-transporting ATPase activity (NAS)
0015917 aminophospholipid transport (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This group of hydrolase enzymes is structurally different from the alpha/beta hydrolase family (abhydrolase). This group includes L-2-haloacid dehalogenase.poxide hydrolases and phosphatases. The structure consists of two domains. One is an inserted four helix bundle.hich is the least well conserved region of the alignment.etween residues 16 and 96 of HAD1_PSESP. The rest of the fold is composed of the core alpha/beta domain.
  IPR005834:Haloacid dehalogenase-like hydrolase
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.P-ATPases (sometime known as E1-E2 ATPases) () are found in bacteria and in a number of eukaryotic plasma membranes and organelles . P-ATPases function to transport a variety of different compounds.ncluding ions and phospholipids.cross a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases.ach of which transports a specific type of ion: H+.a+.+.g2+.a2+.g+ and Ag2+.n2+.o2+.b2+.i2+.d2+.u+ and Cu2+. P-ATPases can be composed of one or two polypeptides.nd can usually assume two main conformations called E1 and E2. This entry represents the several classes of P-type ATPases.ncluding those that transport K+ ().g2+ ().d2+ ().u 2+ ().n2+ ().a+ ().a2+ ().a+/K+ ().nd H+/K+ (). These P-ATPases are found in both prokaryotes and eukaryotes.More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR001757:ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
These sequences represent the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other . These ATPases are found only in eukaryotes.
  IPR006539:Phospholipid-translocating P-type ATPase, flippase
IPR005834:Hydrolase 
Evalue:-3 
Location:410-843IPR001757:ATPase_P-type 
Evalue:0 
Location:128-226
SequencesProtein: ATP9B_HUMAN (1095 aa)
mRNA: NM_198531
Local Annotation
Synapse Ontology
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentK01530
  Level 3 annotation:
    phospholipid-translocating ATPase
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 45 residues, 74930384-74930517Exon2: 60 residues, 74957463-74957637Exon3: 52 residues, 74971342-74971493Exon4: 40 residues, 74974228-74974342Exon5: 38 residues, 74987254-74987363Exon6: 21 residues, 75004789-75004848Exon7: 19 residues, 75015491-75015543Exon8: 33 residues, 75037800-75037895Exon9: 29 residues, 75054170-75054251Exon10: 27 residues, 75067924-75068000Exon11: 27 residues, 75074949-75075026Exon12: 55 residues, 75114368-75114529Exon13: 49 residues, 75138041-75138184Exon14: 39 residues, 75164591-75164704Exon15: 85 residues, 75167973-75168222Exon16: 56 residues, 75190128-75190290Exon17: 33 residues, 75190999-75191092Exon18: 30 residues, 75197615-75197699Exon19: 59 residues, 75198266-75198437Exon20: 35 residues, 75203255-75203354Exon21: 32 residues, 75205252-75205342Exon22: 50 residues, 75206415-75206560Exon23: 23 residues, 75206762-75206827Exon24: 54 residues, 75208757-75208913Exon25: 23 residues, 75209119-75209184Exon26: 38 residues, 75220341-75220450Exon27: 21 residues, 75233812-75233870Exon28: 70 residues, 75234885-75235089Exon29: 13 residues, 75236381-75236414Exon30: 346 residues, 75238234-75239268Exon31: 2 residues, -Jump to ATP9B_HUMAN  
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Loci Cluster (Details)Loci: 3074 74930384-75239268 ~-309K 17451(ATP9B)(+)Loci: 3073 74841262-74859179 ~-18K 17450(SALL3)(+)Link out to UCSC