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0ATF5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameATF5
DescriptionCyclic-amp-dependent transcription factor atf-5 (activating transcription factor 5) (transcription factor atfx).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003702 RNA polymerase II transcription factor acti... (TAS)
0003714 transcription corepressor activity (TAS)
0000074 regulation of progression through cell cycle (TAS)
0006357 regulation of transcription from RNA polyme... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The basic-leucine zipper (bZIP) transcription factors .f eukaryotic are proteins that contain a basic region mediating sequence-specific DNA-binding followed by a leucine zipper region (see ) required for dimerization.
  IPR004827:Basic-leucine zipper (bZIP) transcription factor
The basic-leucine zipper (bZIP) transcription factors .f eukaryotic are proteins that contain a basic region mediating sequence-specific DNA-binding followed by a leucine zipper region (see ) required for dimerization.
  IPR011616:bZIP transcription factor, bZIP_1
Wilms tumour (WT) is an embryonal malignancy of the kidney.ffecting around 1 in 10.00 infants. It occurs in both sporadic and hereditary forms. Inactivation of WT1 is one of the causes of Wilms tumour. Defects in the WT1 gene are also associated with Denys-Drash Syndrome (DDS).hich is characterised by typical nephropathy and genital abnormalities. The WT1 gene product shows similarity to the zinc fingers of the mammalian growth regulated EGR1 and EGR2 proteins .
  IPR000976:Wilm's tumour protein
The DNA-binding domain of certain eukaryotic transcription factors displays a distinctive helix-turn-helix (HTH) motif. The MafG basic region-leucine zipper (bZIP) protein and the C. elegans Skn-1 transcription factor share this HTH motif. MafG is a member of the Maf family of proteins.hich are a subgroup of bZIP proteins that function as transcriptional regulators of cellular differentiation. Mafs can form either homodimers.r heterodimers with other bZIP proteins through their leucine zipper domains. MafG proteins are small Mafs that lack a putative transactivation domain. The DNA-binding domain of MafG contains the conserved Maf extended homology region (EHR).hich is not present in other bZIP proteins. The EHR together with the basic region are responsible for the DNA-binding specificity of Mafs. Skn-1 is a transcription factor that specifies mesodermal development in C. elegans. Skn-1 and MafG share a conserved DNA-binding motif.owever Skn-1 lacks the leucine zipper dimerisation domain that is found in all bZIP proteins. Skn-1 acts as a monomer. The DNA-binding domains in MafG and Skn-1 share structural similarity.espite a sequence identity of only 25%. The domain fold consists of three (MafG) to four (Skn-1) helices.here the long C-terminal helix protrudes from the domain and binds to DNA. MafG lacks the N-terminal helix of Skn-1. A basic cluster of residues is present on the surface of the domain.hich together with the amino acid sequence motif.XXYAXXCR.orms a DNA-binding surface. MafG and Skn-1 may use a common DNA-binding mode. However.he involvement of helix 2 (H2) in DNA recognition differs between MafG and Skn-1.ith two residues at the beginning of H2 in MafG contributing to the unique DNA-binding specificity of Mafs. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008917:Eukaryotic transcription factor, DNA-binding
IPR004827:BRLZ 
Evalue:-13.3665315444204 
Location:206-270IPR000976:WILMSTUMOUR 
Evalue:0 
Location:0-0
SequencesProtein: ATF5_HUMAN (282 aa)
mRNA: NM_012068
Local Annotation
Synapse Ontology
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 67 residues, 55124271-55124469Exon2: 101 residues, 55125800-55126097Exon3: 506 residues, 55127490-55129003Exon4: 2 residues, -Jump to ATF5_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3124 53589943-53639205 ~-49K 19224(GRIN2D)(+)Loci: 3125 53656317-53661179 ~-5K 19226(KCNJ14)(+)Loci: 3126 53747240-53794495 ~-47K 19229(SULT2B1)(+)Loci: 4406 53833083-53841263 ~-8K 19240(CA11)(-)Loci: 4407 53990131-54006113 ~-16K 19255(BCAT2)(-)Loci: 4408 54262487-54268010 ~-6K 19284(-)Loci: 3127 54309429-54313528 ~-4K 19290(LIN7B)(+)Loci: 3128 54314474-54346090 ~-32K 19292(PPFIA3)(+)Loci: 4409 54484705-54520286 ~-36K 19297(SLC6A16)(-)Loci: 3129 54669297-54681299 ~-12K 19311(FLT3LG)(+)Loci: 4410 54854641-54860926 ~-6K 19323(IRF3)(-)Loci: 3130 54886218-54908800 ~-23K 19334(CPT1C)(+)Loci: 3131 54961991-55002179 ~-40K 19337(AP2A1)(+)Loci: 3132 55124271-55129003 ~-5K 19355(ATF5)(+)Loci: 4411 55510576-55524446 ~-14K 19365(KCNC3)(-)Loci: 4412 55817047-55833114 ~-16K 19382(SYT3)(-)Loci: 4413 55856895-55912007 ~-55K 19383(SHANK1)(-)Loci: 3123 53559468-53571439 ~-12K 19220(SYNGR4)(+)Link out to UCSC