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0AT5F1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameATP5F1
DescriptionAtp synthase b chain, mitochondrial precursor (ec 3.6.3.14).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005759 mitochondrial matrix (TAS)
0005215 transporter activity (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.F-ATPases (also known as F1F0-ATPase.r H(+)-transporting two-sector ATPase) () are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha.eta.amma.elta.psilon).hile the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C).ine in mitochondria (A-G.6.8). Both the F1 and F0 complexes are rotary motors that are coupled back-to-back. In the F1 complex.he central gamma subunit forms the rotor inside the cylinder made of the alpha(3)beta(3) subunits.hile in the F0 complex.he ring-shaped C subunits forms the rotor. The two rotors rotate in opposite directions.ut the F0 rotor is usually stronger.sing the force from the proton gradient to push the F1 rotor in reverse in order to drive ATP synthesis . These ATPases can also work in reverse to hydrolyse ATP to create a proton gradient.This entry represents subunit B from the F0 complex in F-ATPases found in mitochondria of eukaryotes (metazoa.iridiplantae (plants and green algae).akobidae and the malawimonadidae). The B subunits are part of the peripheral stalk that links the F1 and F0 complexes together.nd which acts as a stator to prevent certain subunits from rotating with the central rotary element. The peripheral stalk differs in subunit composition between mitochondrial.hloroplast and bacterial F-ATPases. In mitochondria.he peripheral stalk is composed of one copy each of subunits OSCP (oligomycin sensitivity conferral protein).6. and D .More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR008688:ATPase, F0 complex, subunit B, mitochondrial
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.F-ATPases (also known as F1F0-ATPase.r H(+)-transporting two-sector ATPase) () are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha.eta.amma.elta.psilon).hile the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C).ine in mitochondria (A-G.6.8). Both the F1 and F0 complexes are rotary motors that are coupled back-to-back. In the F1 complex.he central gamma subunit forms the rotor inside the cylinder made of the alpha(3)beta(3) subunits.hile in the F0 complex.he ring-shaped C subunits forms the rotor. The two rotors rotate in opposite directions.ut the F0 rotor is usually stronger.sing the force from the proton gradient to push the F1 rotor in reverse in order to drive ATP synthesis . These ATPases can also work in reverse to hydrolyse ATP to create a proton gradient.This entry represents subunit B from the F0 complex in F-ATPases found in mitochondria of the metazoa. The B subunits are part of the peripheral stalk that links the F1 and F0 complexes together.nd which acts as a stator to prevent certain subunits from rotating with the central rotary element. The peripheral stalk differs in subunit composition between mitochondrial.hloroplast and bacterial F-ATPases. In mitochondria.he peripheral stalk is composed of one copy each of subunits OSCP (oligomycin sensitivity conferral protein).6. and D .More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR013837:ATPase, F0 complex subunit B, mitochondrial, metazoa
IPR008688:Mt_ATP-synt_B 
Evalue:-56.8538703918457 
Location:83-244
SequencesProtein: AT5F1_HUMAN (256 aa)
mRNA: NM_001688
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK02127
  Level 3 annotation:
    F-type H+-transporting ATPase subunit b
  Level 2 annotation:
    ATP synthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 154 residues, 111793265-111793726Exon2: 14 residues, 111793981-111794018Exon3: 50 residues, 111798355-111798501Exon4: 56 residues, 111800230-111800394Exon5: 44 residues, 111800774-111800900Exon6: 62 residues, 111803601-111803781Exon7: 330 residues, 111805061-111806046Exon8: 2 residues, -Jump to AT5F1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3819 111843577-111848266 ~-5K 2174(ADORA3)(-)Loci: 2538 111963927-112057623 ~-94K 2175(RAP1A)(+)Loci: 2539 112099776-112111721 ~-12K 2178(DDX20)(+)Loci: 3820 112119976-112333300 ~-213K 2180(KCND3)(-)Loci: 2537 111793265-111806046 ~-13K 2169(ATP5F1)(+)Link out to UCSC