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0AT2B1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameATP2B1
DescriptionPlasma membrane calcium-transporting atpase 1 (ec 3.6.3.8) (pmca1) (plasma membrane calcium pump isoform 1) (plasma membrane calcium atpase isoform 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005388 calcium-transporting ATPase activity (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
P-type (or E1-E2-type) ATPases constitute a superfamily of cation transport enzymes.resent both in prokaryota and eukaryota.hose members mediate membrane flux of all common biologically relevant cations . The enzymes.hat form an aspartyl phosphate intermediate in the course of ATP hydrolysis.an be divided into 4 major groups : (1) Ca2+-transporting ATPases; (2) Na+/K+- and gastric H+/K+-transporting ATPases; (3) plasma membrane H+-transporting ATPases (proton pumps) of plants.ungi and lower eukaryotes; and (4) all bacterial P-type ATPases.xcept the Mg2+-ATPase of Salmonella typhimurium.hich is more similar to the eukaryotic sequences. However.reat variety of sequence analysis methods results in diversity of classification.
  IPR008250:E1-E2 ATPase-associated region
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.P-ATPases (sometime known as E1-E2 ATPases) () are found in bacteria and in a number of eukaryotic plasma membranes and organelles . P-ATPases function to transport a variety of different compounds.ncluding ions and phospholipids.cross a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases.ach of which transports a specific type of ion: H+.a+.+.g2+.a2+.g+ and Ag2+.n2+.o2+.b2+.i2+.d2+.u+ and Cu2+. P-ATPases can be composed of one or two polypeptides.nd can usually assume two main conformations called E1 and E2. This entry represents the conserved C-terminal region found in several classes of cation-transporting P-type ATPases.ncluding those that transport H+ ().a+ ().a2+ ().a+/K+ ().nd H+/K+ (). In the H+/K+- and Na+/K+-exchange P-ATPases.his domain is found in the catalytic alpha chain.More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR006068:ATPase, P-type cation-transporter, C-terminal
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.P-ATPases (sometime known as E1-E2 ATPases) () are found in bacteria and in a number of eukaryotic plasma membranes and organelles . P-ATPases function to transport a variety of different compounds.ncluding ions and phospholipids.cross a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases.ach of which transports a specific type of ion: H+.a+.+.g2+.a2+.g+ and Ag2+.n2+.o2+.b2+.i2+.d2+.u+ and Cu2+. P-ATPases can be composed of one or two polypeptides.nd can usually assume two main conformations called E1 and E2. This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases.ncluding those that transport H+ ().a+ ().a2+ ().a+/K+ ().nd H+/K+ (). In the H+/K+- and Na+/K+-exchange P-ATPases.his domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases.his domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases .More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR004014:ATPase, P-type cation-transporter, N-terminal
This group of hydrolase enzymes is structurally different from the alpha/beta hydrolase family (abhydrolase). This group includes L-2-haloacid dehalogenase.poxide hydrolases and phosphatases. The structure consists of two domains. One is an inserted four helix bundle.hich is the least well conserved region of the alignment.etween residues 16 and 96 of HAD1_PSESP. The rest of the fold is composed of the core alpha/beta domain.
  IPR005834:Haloacid dehalogenase-like hydrolase
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.P-ATPases (sometime known as E1-E2 ATPases) () are found in bacteria and in a number of eukaryotic plasma membranes and organelles . P-ATPases function to transport a variety of different compounds.ncluding ions and phospholipids.cross a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases.ach of which transports a specific type of ion: H+.a+.+.g2+.a2+.g+ and Ag2+.n2+.o2+.b2+.i2+.d2+.u+ and Cu2+. P-ATPases can be composed of one or two polypeptides.nd can usually assume two main conformations called E1 and E2. This entry represents the several classes of P-type ATPases.ncluding those that transport K+ ().g2+ ().d2+ ().u 2+ ().n2+ ().a+ ().a2+ ().a+/K+ ().nd H+/K+ (). These P-ATPases are found in both prokaryotes and eukaryotes.More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR001757:ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
This family describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes .ut of the cell. In some organisms.his type of pump may also be found in vacuolar membranes . In humans and mice.t least.here are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly.here are no human diseases linked to PMCA defects.lthough alterations of PMCA function do elicit physiological effects . The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump .
  IPR006408:Calcium-translocating P-type ATPase, PMCA-type
IPR008250:E1-E2_ATPase 
Evalue:-36.5376014709473 
Location:158-465IPR006068:Cation_ATPase_C 
Evalue:-28.2441253662109 
Location:914-1065IPR004014:Cation_ATPase_N 
Evalue:-21.6382713317871 
Location:44-127IPR005834:Hydrolase 
Evalue:-17.4685211181641 
Location:469-818IPR001757:CATATPASE 
Evalue:0 
Location:819-831
SequencesProtein: AT2B1_HUMAN (1258 aa)
mRNA: NM_001001323
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentK05850
  Level 3 annotation:
    Ca2+ transporting ATPase, plasma membrane
  Level 2 annotation:
    ATPases
    Calcium signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1082 residues, 88505958-88509203Exon2: 53 residues, 88516497-88516651Exon3: 63 residues, 88517024-88517207Exon4: 38 residues, 88519233-88519341Exon5: 72 residues, 88520950-88521162Exon6: 73 residues, 88521619-88521833Exon7: 66 residues, 88522062-88522254Exon8: 37 residues, 88527844-88527951Exon9: 31 residues, 88528328-88528416Exon10: 62 residues, 88529100-88529280Exon11: 81 residues, 88534709-88534947Exon12: 82 residues, 88537906-88538148Exon13: 83 residues, 88539456-88539699Exon14: 73 residues, 88542090-88542305Exon15: 56 residues, 88544361-88544523Exon16: 15 residues, 88545585-88545624Exon17: 49 residues, 88548412-88548553Exon18: 44 residues, 88552685-88552811Exon19: 87 residues, 88552904-88553159Exon20: 68 residues, 88560065-88560263Exon21: 131 residues, 88573586-88573975Exon22: 2 residues, -Jump to AT2B1_HUMAN  
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