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0AT2A3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameATP2A3
DescriptionSarcoplasmic/endoplasmic reticulum calcium atpase 3 (ec 3.6.3.8) (calcium pump 3) (serca3) (sr ca(2+)-atpase 3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005388 calcium-transporting ATPase activity (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
P-type (or E1-E2-type) ATPases constitute a superfamily of cation transport enzymes.resent both in prokaryota and eukaryota.hose members mediate membrane flux of all common biologically relevant cations . The enzymes.hat form an aspartyl phosphate intermediate in the course of ATP hydrolysis.an be divided into 4 major groups : (1) Ca2+-transporting ATPases; (2) Na+/K+- and gastric H+/K+-transporting ATPases; (3) plasma membrane H+-transporting ATPases (proton pumps) of plants.ungi and lower eukaryotes; and (4) all bacterial P-type ATPases.xcept the Mg2+-ATPase of Salmonella typhimurium.hich is more similar to the eukaryotic sequences. However.reat variety of sequence analysis methods results in diversity of classification.
  IPR008250:E1-E2 ATPase-associated region
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.P-ATPases (sometime known as E1-E2 ATPases) () are found in bacteria and in a number of eukaryotic plasma membranes and organelles . P-ATPases function to transport a variety of different compounds.ncluding ions and phospholipids.cross a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases.ach of which transports a specific type of ion: H+.a+.+.g2+.a2+.g+ and Ag2+.n2+.o2+.b2+.i2+.d2+.u+ and Cu2+. P-ATPases can be composed of one or two polypeptides.nd can usually assume two main conformations called E1 and E2. This entry represents the conserved C-terminal region found in several classes of cation-transporting P-type ATPases.ncluding those that transport H+ ().a+ ().a2+ ().a+/K+ ().nd H+/K+ (). In the H+/K+- and Na+/K+-exchange P-ATPases.his domain is found in the catalytic alpha chain.More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR006068:ATPase, P-type cation-transporter, C-terminal
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.P-ATPases (sometime known as E1-E2 ATPases) () are found in bacteria and in a number of eukaryotic plasma membranes and organelles . P-ATPases function to transport a variety of different compounds.ncluding ions and phospholipids.cross a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases.ach of which transports a specific type of ion: H+.a+.+.g2+.a2+.g+ and Ag2+.n2+.o2+.b2+.i2+.d2+.u+ and Cu2+. P-ATPases can be composed of one or two polypeptides.nd can usually assume two main conformations called E1 and E2. This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases.ncluding those that transport H+ ().a+ ().a2+ ().a+/K+ ().nd H+/K+ (). In the H+/K+- and Na+/K+-exchange P-ATPases.his domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases.his domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases .More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR004014:ATPase, P-type cation-transporter, N-terminal
This group of hydrolase enzymes is structurally different from the alpha/beta hydrolase family (abhydrolase). This group includes L-2-haloacid dehalogenase.poxide hydrolases and phosphatases. The structure consists of two domains. One is an inserted four helix bundle.hich is the least well conserved region of the alignment.etween residues 16 and 96 of HAD1_PSESP. The rest of the fold is composed of the core alpha/beta domain.
  IPR005834:Haloacid dehalogenase-like hydrolase
H+-Transporting ATPases (proton pumps) are the main ion pumps in the plasma membrane and play acentral role in the physiology and bioenergetics of plant cells. They are the primaryactive transporters of the plasma membrane and are responsible for generating the membrane potentialthat drives translocation of cations.mino-acids.ugars.nd hormones.hilst also contributing tothe maintenance of intracellular and extracellular pH and cell turgor . Proton pumps aremembers of the P-type (or E1-E2-type) cation-transporting ATPase superfamily.hich has evolved froma common ancestral gene . The sequences are believed to contain 8-10 transmembrane helices.ome of which are well conserved throughout the superfamily. They may thus all operate via a similarmechanism.ith an aspartylphosphoryl enzyme intermediate being formed during the catalyticcycle.
  IPR000695:H+ transporting ATPase, proton pump
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.P-ATPases (sometime known as E1-E2 ATPases) () are found in bacteria and in a number of eukaryotic plasma membranes and organelles . P-ATPases function to transport a variety of different compounds.ncluding ions and phospholipids.cross a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases.ach of which transports a specific type of ion: H+.a+.+.g2+.a2+.g+ and Ag2+.n2+.o2+.b2+.i2+.d2+.u+ and Cu2+. P-ATPases can be composed of one or two polypeptides.nd can usually assume two main conformations called E1 and E2. This entry represents the several classes of P-type ATPases.ncluding those that transport K+ ().g2+ ().d2+ ().u 2+ ().n2+ ().a+ ().a2+ ().a+/K+ ().nd H+/K+ (). These P-ATPases are found in both prokaryotes and eukaryotes.More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR001757:ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
This model describes Ca2+ ATPases () from eukaryotes and includes significantrepresentatives from plants. Plasma membrane Ca2+ ATPases are primarily responsible for extrusion of calcium from cytoplasmic milieu to outside.oupled to the hydrolyis of ATP. Besides Ca2+ ATPases.a+/Ca2+ exchangers are also involved in the maintenance of Ca2+ homestasis in the cell.
  IPR005782:Calcium ATPase
IPR008250:E1-E2_ATPase 
Evalue:-124.275726318359 
Location:93-341IPR006068:Cation_ATPase_C 
Evalue:-78.9208221435547 
Location:819-990IPR004014:Cation_ATPase_N 
Evalue:-26.9586067199707 
Location:1-77IPR005834:Hydrolase 
Evalue:-19.4559326171875 
Location:345-724IPR000695:HATPASE 
Evalue:0 
Location:732-757
SequencesProtein: AT2A3_HUMAN (1043 aa)
mRNA: NM_174953 NM_174954 NM_174955 NM_174956
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK05853
  Level 3 annotation:
    Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum
  Level 2 annotation:
    ATPases
    Calcium signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 523 residues, 3773917-3775484Exon2: 31 residues, 3778282-3778370Exon3: 41 residues, 3778705-3778823Exon4: 41 residues, 3779370-3779488Exon5: 46 residues, 3780343-3780477Exon6: 30 residues, 3785234-3785320Exon7: 69 residues, 3786309-3786512Exon8: 75 residues, 3787458-3787679Exon9: 114 residues, 3791013-3791349Exon10: 75 residues, 3791478-3791697Exon11: 44 residues, 3792648-3792774Exon12: 46 residues, 3793433-3793565Exon13: 36 residues, 3794746-3794849Exon14: 31 residues, 3795102-3795191Exon15: 157 residues, 3797433-3797898Exon16: 30 residues, 3800553-3800639Exon17: 29 residues, 3800735-3800816Exon18: 48 residues, 3801293-3801432Exon19: 37 residues, 3801623-3801728Exon20: 29 residues, 3803389-3803472Exon21: 8 residues, 3803735-3803753Exon22: 91 residues, 3814216-3814485Exon23: 2 residues, -Jump to AT2A3_HUMANExon1: 523 residues, 3773917-3775484Exon2: 21 residues, 3778023-3778081Exon3: 35 residues, 3778269-3778370Exon4: 41 residues, 3778705-3778823Exon5: 41 residues, 3779370-3779488Exon6: 46 residues, 3780343-3780477Exon7: 30 residues, 3785234-3785320Exon8: 69 residues, 3786309-3786512Exon9: 75 residues, 3787458-3787679Exon10: 114 residues, 3791013-3791349Exon11: 75 residues, 3791478-3791697Exon12: 44 residues, 3792648-3792774Exon13: 46 residues, 3793433-3793565Exon14: 36 residues, 3794746-3794849Exon15: 31 residues, 3795102-3795191Exon16: 157 residues, 3797433-3797898Exon17: 30 residues, 3800553-3800639Exon18: 29 residues, 3800735-3800816Exon19: 48 residues, 3801293-3801432Exon20: 37 residues, 3801623-3801728Exon21: 29 residues, 3803389-3803472Exon22: 8 residues, 3803735-3803753Exon23: 91 residues, 3814216-3814485Exon24: 2 residues, -Jump to AT2A3_HUMANExon1: 523 residues, 3773917-3775484Exon2: 21 residues, 3778023-3778081Exon3: 31 residues, 3778282-3778370Exon4: 41 residues, 3778705-3778823Exon5: 41 residues, 3779370-3779488Exon6: 46 residues, 3780343-3780477Exon7: 30 residues, 3785234-3785320Exon8: 69 residues, 3786309-3786512Exon9: 75 residues, 3787458-3787679Exon10: 114 residues, 3791013-3791349Exon11: 75 residues, 3791478-3791697Exon12: 44 residues, 3792648-3792774Exon13: 46 residues, 3793433-3793565Exon14: 36 residues, 3794746-3794849Exon15: 31 residues, 3795102-3795191Exon16: 157 residues, 3797433-3797898Exon17: 30 residues, 3800553-3800639Exon18: 29 residues, 3800735-3800816Exon19: 48 residues, 3801293-3801432Exon20: 37 residues, 3801623-3801728Exon21: 29 residues, 3803389-3803472Exon22: 8 residues, 3803735-3803753Exon23: 91 residues, 3814216-3814485Exon24: 2 residues, -Jump to AT2A3_HUMANExon1: 523 residues, 3773917-3775484Exon2: 35 residues, 3778269-3778370Exon3: 41 residues, 3778705-3778823Exon4: 41 residues, 3779370-3779488Exon5: 46 residues, 3780343-3780477Exon6: 30 residues, 3785234-3785320Exon7: 69 residues, 3786309-3786512Exon8: 75 residues, 3787458-3787679Exon9: 114 residues, 3791013-3791349Exon10: 75 residues, 3791478-3791697Exon11: 44 residues, 3792648-3792774Exon12: 46 residues, 3793433-3793565Exon13: 36 residues, 3794746-3794849Exon14: 31 residues, 3795102-3795191Exon15: 157 residues, 3797433-3797898Exon16: 30 residues, 3800553-3800639Exon17: 29 residues, 3800735-3800816Exon18: 48 residues, 3801293-3801432Exon19: 37 residues, 3801623-3801728Exon20: 29 residues, 3803389-3803472Exon21: 8 residues, 3803735-3803753Exon22: 91 residues, 3814216-3814485Exon23: 2 residues, -Jump to AT2A3_HUMAN  
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Loci Cluster (Details)Loci: 4249 2912712-2913651 ~-1K 14853(OR1D5)(-)Loci: 4250 2976653-2977595 ~-1K 14854(OR1G1)(-)Loci: 4251 3127934-3129018 ~-1K 14856(OR3A2)(-)Loci: 2967 3270617-3271577 ~-1K 14858(OR3A3)(+)Loci: 2968 3486764-3511581 ~-25K 14869(CTNS)(+)Loci: 2969 3573945-3576739 ~-3K 14877(GSG2)(+)Loci: 4252 3710373-3743086 ~-33K 14879(CAMKK1)(-)Loci: 4253 3773917-3814485 ~-41K 14884(ATP2A3)(-)Loci: 4254 4013949-4114000 ~-100K 14897(ANKFY1)(-)Loci: 2966 2443685-2535638 ~-92K 14848(PAFAH1B1)(+)Link out to UCSC