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0AT1A3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameATP1A3
DescriptionSodium/potassium-transporting atpase alpha-3 chain (ec 3.6.3.9) (sodium pump 3) (na+/k+ atpase 3) (alpha(iii)).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005890 potassium-exchanging ATPase complex (ISS)
0005391 potassium-exchanging ATPase activity (ISS)
0015991 ATP hydrolysis coupled proton transport (ISS)
0030641 hydrogen ion homeostasis (ISS)
0006813 potassium ion transport (ISS)
0006814 sodium ion transport (ISS)
0030317 sperm motility (ISS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
P-type (or E1-E2-type) ATPases constitute a superfamily of cation transport enzymes.resent both in prokaryota and eukaryota.hose members mediate membrane flux of all common biologically relevant cations . The enzymes.hat form an aspartyl phosphate intermediate in the course of ATP hydrolysis.an be divided into 4 major groups : (1) Ca2+-transporting ATPases; (2) Na+/K+- and gastric H+/K+-transporting ATPases; (3) plasma membrane H+-transporting ATPases (proton pumps) of plants.ungi and lower eukaryotes; and (4) all bacterial P-type ATPases.xcept the Mg2+-ATPase of Salmonella typhimurium.hich is more similar to the eukaryotic sequences. However.reat variety of sequence analysis methods results in diversity of classification.
  IPR008250:E1-E2 ATPase-associated region
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.P-ATPases (sometime known as E1-E2 ATPases) () are found in bacteria and in a number of eukaryotic plasma membranes and organelles . P-ATPases function to transport a variety of different compounds.ncluding ions and phospholipids.cross a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases.ach of which transports a specific type of ion: H+.a+.+.g2+.a2+.g+ and Ag2+.n2+.o2+.b2+.i2+.d2+.u+ and Cu2+. P-ATPases can be composed of one or two polypeptides.nd can usually assume two main conformations called E1 and E2. This entry represents the conserved C-terminal region found in several classes of cation-transporting P-type ATPases.ncluding those that transport H+ ().a+ ().a2+ ().a+/K+ ().nd H+/K+ (). In the H+/K+- and Na+/K+-exchange P-ATPases.his domain is found in the catalytic alpha chain.More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR006068:ATPase, P-type cation-transporter, C-terminal
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.P-ATPases (sometime known as E1-E2 ATPases) () are found in bacteria and in a number of eukaryotic plasma membranes and organelles . P-ATPases function to transport a variety of different compounds.ncluding ions and phospholipids.cross a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases.ach of which transports a specific type of ion: H+.a+.+.g2+.a2+.g+ and Ag2+.n2+.o2+.b2+.i2+.d2+.u+ and Cu2+. P-ATPases can be composed of one or two polypeptides.nd can usually assume two main conformations called E1 and E2. This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases.ncluding those that transport H+ ().a+ ().a2+ ().a+/K+ ().nd H+/K+ (). In the H+/K+- and Na+/K+-exchange P-ATPases.his domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases.his domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases .More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR004014:ATPase, P-type cation-transporter, N-terminal
This group of hydrolase enzymes is structurally different from the alpha/beta hydrolase family (abhydrolase). This group includes L-2-haloacid dehalogenase.poxide hydrolases and phosphatases. The structure consists of two domains. One is an inserted four helix bundle.hich is the least well conserved region of the alignment.etween residues 16 and 96 of HAD1_PSESP. The rest of the fold is composed of the core alpha/beta domain.
  IPR005834:Haloacid dehalogenase-like hydrolase
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.P-ATPases (sometime known as E1-E2 ATPases) () are found in bacteria and in a number of eukaryotic plasma membranes and organelles . P-ATPases function to transport a variety of different compounds.ncluding ions and phospholipids.cross a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases.ach of which transports a specific type of ion: H+.a+.+.g2+.a2+.g+ and Ag2+.n2+.o2+.b2+.i2+.d2+.u+ and Cu2+. P-ATPases can be composed of one or two polypeptides.nd can usually assume two main conformations called E1 and E2. This entry represents the several classes of P-type ATPases.ncluding those that transport K+ ().g2+ ().d2+ ().u 2+ ().n2+ ().a+ ().a2+ ().a+/K+ ().nd H+/K+ (). These P-ATPases are found in both prokaryotes and eukaryotes.More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR001757:ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.P-ATPases (sometime known as E1-E2 ATPases) () are found in bacteria and in a number of eukaryotic plasma membranes and organelles . P-ATPases function to transport a variety of different compounds.ncluding ions and phospholipids.cross a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases.ach of which transports a specific type of ion: H+.a+.+.g2+.a2+.g+ and Ag2+.n2+.o2+.b2+.i2+.d2+.u+ and Cu2+. P-ATPases can be composed of one or two polypeptides.nd can usually assume two main conformations called E1 and E2. This entry represents the alpha subunit found in the P-type cation exchange ATPases located in the plasma membranes of animal cells. These P-ATPases include both H+/K+-ATPases () and Na+/K+-ATPases ().hich belong to the IIC subfamily of ATPases . These ATPases catalyse the hydrolysis of ATP coupled with the exchange of cations.umping one cation out of the cell (H+ or Na+) in exchange for K+. These ATPases contain an alpha subunit that is the catalytic component.nd a regulatory beta subunit () that stabilizes the alpha/beta assembly . Different alpha and beta isoforms exist.ermitting greater regulatory control.An example of a H+/K+-ATPase is the gastric pump responsible for acid secretion in the stomach.ransporting protons from the cytoplasm of parietal cells to create a large pH gradient in exchange for the internalization of potassium ions.sing ATP hydrolysis to drive the pump .More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR005775:ATPase, P-type cation exchange, alpha subunit, eukaryotic
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.P-ATPases (sometime known as E1-E2 ATPases) () are found in bacteria and in a number of eukaryotic plasma membranes and organelles . P-ATPases function to transport a variety of different compounds.ncluding ions and phospholipids.cross a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases.ach of which transports a specific type of ion: H+.a+.+.g2+.a2+.g+ and Ag2+.n2+.o2+.b2+.i2+.d2+.u+ and Cu2+. P-ATPases can be composed of one or two polypeptides.nd can usually assume two main conformations called E1 and E2. This entry represents the alpha subunit found in the P-type cation exchange ATPases found in the plasma membranes of both prokaryotes and eukaryotes. These P-ATPases include both H+/K+-ATPases () and Na+/K+-ATPases ().hich belong to the IIC subfamily of ATPases . These ATPases catalyse the hydrolysis of ATP coupled with the exchange of cations.umping one cation out of the cell (H+ or Na+) in exchange for K+. These ATPases contain an alpha subunit that is the catalytic component.nd a regulatory beta subunit () that stabilizes the alpha/beta assembly . Different alpha and beta isoforms exist.ermitting greater regulatory control.An example of a H+/K+-ATPase is the gastric pump responsible for acid secretion in the stomach.ransporting protons from the cytoplasm of parietal cells to create a large pH gradient in exchange for the internalization of potassium ions.sing ATP hydrolysis to drive the pump .More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR006069:ATPase, P-type cation exchange, alpha subunit
IPR008250:E1-E2_ATPase 
Evalue:-118.045761108398 
Location:125-356IPR006068:Cation_ATPase_C 
Evalue:-74.4814834594727 
Location:824-1002IPR004014:Cation_ATPase_N 
Evalue:-37.2924308776856 
Location:23-106IPR005834:Hydrolase 
Evalue:-17.1870861053467 
Location:360-728IPR006069:NAKATPASE 
Evalue:0 
Location:777-798IPR001757:CATATPASE 
Evalue:0 
Location:729-741
SequencesProtein: AT1A3_HUMAN (1013 aa)
mRNA: NM_152296
Local Annotation
Synapse Ontology
?
sdb:0243 sodium-potassium pump  (Evidence:keywords)
KO assignmentK01538
  Level 3 annotation:
    Na+/K+-exchanging ATPase
  Level 2 annotation:
    ATPases
    CD molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 128 residues, 47162575-47162957Exon2: 32 residues, 47163240-47163332Exon3: 36 residues, 47163653-47163755Exon4: 45 residues, 47164776-47164907Exon5: 50 residues, 47165426-47165572Exon6: 43 residues, 47166176-47166300Exon7: 53 residues, 47166379-47166534Exon8: 58 residues, 47171620-47171789Exon9: 52 residues, 47172407-47172558Exon10: 47 residues, 47173927-47174064Exon11: 60 residues, 47174142-47174318Exon12: 66 residues, 47174597-47174790Exon13: 47 residues, 47177493-47177628Exon14: 38 residues, 47177713-47177823Exon15: 68 residues, 47177899-47178098Exon16: 91 residues, 47180909-47181178Exon17: 41 residues, 47181297-47181415Exon18: 47 residues, 47181855-47181990Exon19: 40 residues, 47182107-47182221Exon20: 70 residues, 47183927-47184131Exon21: 22 residues, 47184309-47184369Exon22: 31 residues, 47184467-47184554Exon23: 55 residues, 47190062-47190222Exon24: 2 residues, -Jump to AT1A3_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4393 47162575-47190222 ~-28K 18940(ATP1A3)(-)Loci: 4394 47194312-47261797 ~-67K 18941(GRIK5)(-)Loci: 4395 47286962-47340851 ~-54K 18946(POU2F2)(-)Loci: 4396 47394591-47413653 ~-19K 18951(DEDD2)(-)Loci: 4392 47152677-47155311 ~-3K 18939(RABAC1)(-)Link out to UCSC