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0ASPM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameASPM
DescriptionAbnormal spindle-like microcephaly-associated protein (abnormal spindle protein homolog) (asp homolog).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The calponin homology domain (also known as CH-domain) is a superfamily of actin-binding domains found in both cytoskeletal proteins and signal transduction proteins . It comprises the following groups of actin-binding domains:Actinin-type (including spectrin.imbrin.BP-280) (see ).Calponin-type (see ).A comprehensive review of proteins containing this type of actin-binding domains is given in .The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity . Most proteins have two copies of the CH domain.owever some proteins such as calponin and the human vav proto-oncogene () have only a single copy. The structure of an example CH-domain has recently been solved .
  IPR001715:Calponin-like actin-binding
Calmodulin (CaM) is recognized as a major calcium sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding.ermed18-14 and 1-5-10 based on the position of conserved hydrophobic residues .The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca2+-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains.ccounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule .
  IPR000048:IQ calmodulin-binding region
IPR001715:CH 
Evalue:-6.88605642318726 
Location:1111-1261IPR000048:IQ 
Evalue:-4.95860719680786 
Location:1729-1749IPR000048:IQ 
Evalue:-4.79587984085083 
Location:3080-3100IPR000048:IQ 
Evalue:-4.74472761154175 
Location:2385-2405IPR000048:IQ 
Evalue:-4.45593214035034 
Location:2666-2686IPR000048:IQ 
Evalue:-4.37675094604492 
Location:1633-1653IPR000048:IQ 
Evalue:-4.22914791107178 
Location:3030-3050IPR000048:IQ 
Evalue:-4.21467018127441 
Location:2689-2709IPR000048:IQ 
Evalue:-4.21467018127441 
Location:2625-2645IPR000048:IQ 
Evalue:-4.15490198135376 
Location:2955-2975IPR000048:IQ 
Evalue:-3.92081880569458 
Location:2021-2041IPR000048:IQ 
Evalue:-3.88605666160583 
Location:1802-1822IPR000048:IQ 
Evalue:-3.67778062820435 
Location:2408-2428IPR000048:IQ 
Evalue:-3.67778062820435 
Location:1971-1991IPR000048:IQ 
Evalue:-3.65757727622986 
Location:2240-2260IPR000048:IQ 
Evalue:-3.30980396270752 
Location:1875-1895IPR000048:IQ 
Evalue:-3.25181198120117 
Location:2933-2953IPR000048:IQ 
Evalue:-3.18708658218384 
Location:2044-2064IPR000048:IQ 
Evalue:-3.18045616149902 
Location:2739-2759IPR000048:IQ 
Evalue:-3.13667702674866 
Location:1898-1918IPR000048:IQ 
Evalue:-3.11350917816162 
Location:2860-2880IPR000048:IQ 
Evalue:-3.0915150642395 
Location:1752-1772IPR000048:IQ 
Evalue:-3.00877404212952 
Location:1465-1485IPR000048:IQ 
Evalue:-3.00877404212952 
Location:2312-2332IPR000048:IQ 
Evalue:-3.00436472892761 
Location:2335-2355IPR000048:IQ 
Evalue:-2.88605666160583 
Location:1488-1508IPR000048:IQ 
Evalue:-2.79588007926941 
Location:1316-1336IPR000048:IQ 
Evalue:-2.74472761154175 
Location:1560-1580IPR000048:IQ 
Evalue:-2.72124648094177 
Location:2458-2478IPR000048:IQ 
Evalue:-2.67778062820435 
Location:1825-1845IPR000048:IQ 
Evalue:-2.48148608207703 
Location:1348-1368IPR000048:IQ 
Evalue:-2.26760625839233 
Location:1656-1676IPR000048:IQ 
Evalue:-2.18045616149902 
Location:3205-3225IPR000048:IQ 
Evalue:-2.10237288475037 
Location:2263-2283IPR000048:IQ 
Evalue:-2.07572078704834 
Location:3182-3202IPR000048:IQ 
Evalue:-1.92081880569458 
Location:1948-1968IPR000048:IQ 
Evalue:-1.88605666160583 
Location:2910-2930IPR000048:IQ 
Evalue:-1.88605666160583 
Location:1394-1414IPR000048:IQ 
Evalue:-1.85387194156647 
Location:1583-1603IPR000048:IQ 
Evalue:-1.79587996006012 
Location:2883-2903IPR000048:IQ 
Evalue:-1.67778074741364 
Location:2094-2114IPR000048:IQ 
Evalue:-1.61978876590729 
Location:2167-2187IPR000048:IQ 
Evalue:-1.53760194778442 
Location:1679-1699IPR000048:IQ 
Evalue:-1.30980396270752 
Location:2554-2574IPR000048:IQ 
Evalue:-1.25963735580444 
Location:3141-3161IPR000048:IQ 
Evalue:-1.0655015707016 
Location:2481-2501IPR000048:IQ 
Evalue:-1.00877392292023 
Location:1848-1868IPR000048:IQ 
Evalue:-1.0043648481369 
Location:2190-2210IPR000048:IQ 
Evalue:-0.920818746089935 
Location:2531-2551IPR000048:IQ 
Evalue:-0.853871941566467 
Location:2286-2306IPR000048:IQ 
Evalue:-0.585026681423187 
Location:1421-1441IPR000048:IQ 
Evalue:-0.537602007389069 
Location:1443-1463IPR000048:IQ 
Evalue:-0.443697512149811 
Location:1267-1287IPR000048:IQ 
Evalue:-0.420216411352158 
Location:1606-1626IPR000048:IQ 
Evalue:-0.397940009832382 
Location:2067-2087IPR000048:IQ 
Evalue:-0.387216150760651 
Location:1538-1558IPR000048:IQ 
Evalue:-0.0705810710787773 
Location:3053-3073IPR000048:IQ 
Evalue:-0.0222763940691948 
Location:1994-2014IPR001715:CH 
Evalue:0 
Location:920-1056IPR000048:IQ 
Evalue:1.14612803567824 
Location:2115-2137IPR000048:IQ 
Evalue:1.36172783601759 
Location:1773-1795IPR000048:IQ 
Evalue:1.82607480270083 
Location:2138-2160IPR000048:IQ 
Evalue:2.14612803567824 
Location:1509-1535IPR000048:IQ 
Evalue:2.25527250510331 
Location:2813-2835IPR000048:IQ 
Evalue:2.32221929473392 
Location:3116-3138IPR000048:IQ 
Evalue:2.51851393987789 
Location:2999-3021
SequencesProtein: ASPM_HUMAN (3477 aa)
mRNA: NM_018136
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 35 residues, 195320076-195320179Exon2: 58 residues, 195322555-195322725Exon3: 61 residues, 195324008-195324185Exon4: 53 residues, 195325682-195325837Exon5: 66 residues, 195325948-195326141Exon6: 66 residues, 195326602-195326794Exon7: 52 residues, 195327659-195327809Exon8: 72 residues, 195328804-195329014Exon9: 34 residues, 195329836-195329933Exon10: 57 residues, 195331750-195331917Exon11: 1587 residues, 195336183-195340938Exon12: 67 residues, 195353541-195353736Exon13: 45 residues, 195357667-195357796Exon14: 49 residues, 195357911-195358054Exon15: 71 residues, 195358140-195358348Exon16: 76 residues, 195359862-195360084Exon17: 30 residues, 195360622-195360708Exon18: 50 residues, 195360798-195360944Exon19: 60 residues, 195364242-195364418Exon20: 45 residues, 195364939-195365070Exon21: 49 residues, 195365667-195365809Exon22: 24 residues, 195368037-195368105Exon23: 84 residues, 195369102-195369348Exon24: 51 residues, 195370848-195370995Exon25: 37 residues, 195375519-195375624Exon26: 495 residues, 195378083-195379563Exon27: 50 residues, 195379709-195379853Exon28: 101 residues, 195381893-195382190Exon29: 2 residues, -Jump to ASPM_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2578 195504030-195714207 ~-210K 3598(CRB1)(+)Loci: 3856 195320076-195382190 ~-62K 3592(ASPM)(-)Link out to UCSC