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0ARH_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameLDLRAP1
DescriptionLow density lipoprotein receptor adapter protein 1 (autosomal recessive hypercholesterolemia protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The PI domain has a similar structure to the insulin receptor substrate-1 PTB domain. 7-stranded beta-sandwich.apped by a C-terminal helix.However.he PI domain contains an additional short N-terminal helix and alarge insertion between strands 1 and 2.hich forms a helix and 2 longconnecting loops. The substrate peptide fits into a surface cleft formedfrom the C-terminal helix and strand 5 .
  IPR006020:Phosphotyrosine interaction region
Pleckstrin homology (PH) domains are small modular domains that occur once.r occasionally several times.n a large variety of signalling proteins.here they serve as simple targeting domains that recognize only phosphoinositide headgroups . PH domains can target their host protein to the plasma and internal membranes through its association with phosphoinositides. PH domains have a partly opened beta-barrel topology that is capped by an alpha helix. Proteins containing PH domains include pleckstrin (N-terminal).hospholipase C delta-1.eta-spectrin.ynamin.on-of-sevenless.rp1.nc-89.app1 and Rac-alpha kinase.The structure of PH domains is similar to the phosphotyrosine-binding domain (PTB) found in IRS-1 (insulin receptor substrate 1).hc adaptor and Numb; to the Ran-binding domain.ound in Nup nuclear pore complex and Ranbp1; to the Enabled/VASP homology domain 1 (EVH1 domain).ound in Enabled.ASP (vasodilator-stimulated phosphoprotein).omer and WASP actin regulatory protein; to the third domain of FERM.ound in moesin.adixin.zrin.erlin and talin; and to the PH-like domain of neurobeachin.
  IPR011993:Pleckstrin homology-type
IPR006020:PTB 
Evalue:-42.4202164033832 
Location:43-178
SequencesProtein: ARH_HUMAN (308 aa)
mRNA: BC029770 NM_015627
Local Annotation
Synapse Ontology
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
all the components of the clathrin coat, major ones are clathrin and clathrin adaptors.
sdb:0261 clathrin coat component  (Evidence:keywords)
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 38 residues, 25742752-25742864Exon2: 49 residues, 25752999-25753142Exon3: 39 residues, 25753937-25754050Exon4: 40 residues, 25756230-25756345Exon5: 26 residues, 25761721-25761794Exon6: 30 residues, 25762147-25762231Exon7: 45 residues, 25762738-25762869Exon8: 13 residues, 25764250-25764285Exon9: 681 residues, 25765925-25767962Exon10: 2 residues, -Jump to ARH_HUMANExon1: 38 residues, 25742752-25742864Exon2: 49 residues, 25752999-25753142Exon3: 39 residues, 25753937-25754050Exon4: 40 residues, 25756230-25756345Exon5: 26 residues, 25761721-25761794Exon6: 30 residues, 25762147-25762231Exon7: 45 residues, 25762738-25762869Exon8: 13 residues, 25764250-25764285Exon9: 681 residues, 25765925-25767962Exon10: 2 residues, -Jump to ARH_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3784 26099194-26105231 ~-6K 763(STMN1)(-)Loci: 3785 26159901-26197235 ~-37K 764(PAFAH2)(-)Loci: 2492 25742752-25767962 ~-25K 748(LDLRAP1)(+)Link out to UCSC