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0ARGI2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameARG2
DescriptionArginase-2, mitochondrial precursor (ec 3.5.3.1) (arginase ii) (non- hepatic arginase) (kidney-type arginase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0004053 arginase activity (TAS)
0006809 nitric oxide biosynthesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
L-Arginine is converted to nitric oxide and citrulline by the enzyme nitric oxide synthase and by the enzyme arginase as a part of the hepatic urea cycle. Arginase is a manganese metalloenzymes containing a metal-activated hydroxide ion. critical nucleophile in metalloenzymes that catalyze hydrolysis or hydration reactions. A hydrogen bond formed by the metal-bound hydroxide holds the enzyme in the proper orientation for catalysis however nonmetal substrate-binding sites are also implicated in the enzyme mechanism. Regeneration of metal-bound hydroxide ion from a metal-bound water molecule requires proton transfer to bulk solvent mediated by a histidine proton shuttle residue.
  IPR005924:Arginase
The ureohydrolase superfamily includes arginase ().gmatinase ().ormiminoglutamase () and proclavaminate amidinohydrolase () . These enzymes share a 3-layer alpha-beta-alpha structure .nd play important roles in arginine/agmatine metabolism.he urea cycle.istidine degradation.nd other pathways. Arginase.hich catalyses the conversion of arginine to urea and ornithine.s one of the five members of the urea cycle enzymes that convert ammoniato urea as the principal product of nitrogen excretion . There are several arginase isozymes that differ in catalytic.olecular and immunological properties. Deficiency in the liver isozyme leads to argininemia.hich is usually associated with hyperammonemia.Agmatinase hydrolyses agmatine to putrescine.he precursor for the biosynthesis of higher polyamines.permidine and spermine. In addition.gmatine may play an important regulatory role in mammals. Formiminoglutamase catalyses the fourth step in histidine degradation.cting to hydrolyse N-formimidoyl-L-glutamate to L-glutamate and formamide. Proclavaminate amidinohydrolase is involved in clavulanic acid biosynthesis. Clavulanic acid acts as an inhibitor of a wide range of beta-lactamase enzymes that are used by various microorganisms to resist beta-lactam antibiotics. As a result.his enzyme improves the effectiveness of beta-lactamase antibiotics .
  IPR006035:Ureohydrolase
IPR006035:Arginase 
Evalue:-141.744720458984 
Location:22-327
SequencesProtein: ARGI2_HUMAN (354 aa)
mRNA: NM_001172
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01476
  Level 3 annotation:
    arginase
  Level 2 annotation:
    Arginine and proline metabolism
    Urea cycle and metabolism of amino groups
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 76 residues, 67156331-67156558Exon2: 26 residues, 67157363-67157436Exon3: 61 residues, 67178655-67178833Exon4: 55 residues, 67182112-67182272Exon5: 33 residues, 67183113-67183208Exon6: 37 residues, 67183390-67183495Exon7: 47 residues, 67184516-67184653Exon8: 336 residues, 67187184-67188187Exon9: 2 residues, -Jump to ARGI2_HUMAN  
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Loci Cluster (Details)Loci: 2850 67156331-67188187 ~-32K 11338(ARG2)(+)Loci: 4135 67187618-67211301 ~-24K 11340(VTI1B)(-)Loci: 4136 67213270-67232213 ~-19K 11341(RDH11)(-)Loci: 2849 66777773-66872288 ~-95K 11329(MPP5)(+)Link out to UCSC