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0AQP2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionAquaporin-2 (aqp-2) (aquaporin-cd) (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (collecting duct water channel protein) (wch-cd).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005886 plasma membrane (TAS)
0015250 water channel activity (TAS)
0007588 excretion (TAS)
0006833 water transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of transmembrane (TM) channel proteins can be grouped together on the basis of sequence similarities . These include: Mammalian major intrinsic protein (MIP). MIP is the major component of lens fibre gap junctions. Mammalian aquaporins . These proteins form water-specific channels that provide the plasma membranes of red cells and kidney proximal and collecting tubules with high permeability to water.hereby permitting water to move in the direction of an osmotic gradient. Soybean nodulin-26. major component of the peribacteroid membrane induced during nodulation in legume roots after Rhizobium infection. Plants tonoplast intrinsic proteins (TIP). There are various isoforms of TIP: alpha (seed).amma.t (root).nd Wsi (water-stress induced). These proteins may allow the diffusion of water.mino acids and/or peptides from the tonoplast interior to the cytoplasm.. Bacterial glycerol facilitator protein (gene glpF).hich facilitates the movement of glycerol across the cytoplasmic membrane. Salmonella typhimurium propanediol diffusion facilitator (gene pduF). Yeast FPS1. glycerol uptake/efflux facilitator protein. Drosophila neurogenic protein big brain (bib). This protein may mediate intercellular communication; it may functions by allowing the transport of certain molecules(s) and thereby sending a signal for an exodermal cell to become an epidermoblast instead of a neuroblast. Yeast hypothetical protein YFL054c. A hypothetical protein from the pepX region of Lactococcus lactis. MIP family proteins are thought to contain 6 TM domains. Sequence analysis suggests that the proteins may have arisen through tandem.ntragenic duplication from an ancestral protein that contained 3 TM domains . Some of the proteins in this group are responsible for the molecular basis of the blood group antigens.urface markers on the outside of the red blood cell membrane. Most of these markers are proteins.ut some are carbohydrates attached to lipids or proteins . Aquaporin-CHIP (Aquaporin 1) belongs to the Colton blood group system and is associated with Co(a/b) antigen.
  IPR000425:Major intrinsic protein
Aquaporins are water channels.resent in both higher and lower organisms.hat belong to the major intrinsic protein family. Most aquaporins are highly selective for water.hough some also facilitate the movement of small uncharged molecules such as glycerol . In higher eukaryotes these proteins play diverse roles in the maintenance of water homeostasis.ndicating that membrane water permeability can be regulated independently of solute permeability. In microorganisms however.any of which do not contain aquaporins.hey are not appeart to play such a broad role. Instead.hey assist specific microbial lifestyles within the environment.g htey confer protection against freeze-thaw stress and may help maintain water permeability at low temperatures . The regulation of aquaporins is complex.ncluding transcriptional.ost-translational.rotein-trafficking and channel-gating mechanisms that are frequently distinct for each family member.Structural studies show that aquaporins are present in the membrane as tetramers.hough each monomer contains its own channel . The monomer has an overall "hourglass" structure made up of three structural elements: an external vestibule.n internal vestibule.nd an extended pore which connects the two vestibules. Substrate selectivity is conferred by two mechanisms. Firstly.he diameter of the pore physically limits the size of molecules that can pass through the channel. Secondly.pecific amino acids within the molecule regulate the preference for hydrophobic or hydrophilic substrates.
SequencesProtein: AQP2_HUMAN (271 aa)
mRNA: NM_000486
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 149 residues, 48630795-48631240Exon2: 57 residues, 48634204-48634369Exon3: 29 residues, 48634679-48634760Exon4: 1162 residues, 48635448-48638929Exon5: 2 residues, -Jump to AQP2_HUMAN  
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Loci Cluster (Details)Loci: 4027 47682322-47698859 ~-17K 8773(PRKAG1)(-)Loci: 4028 47744734-47750042 ~-5K 8775(-)Loci: 4029 47807832-47811571 ~-4K 8784(-)Loci: 4030 47864851-47869128 ~-4K 8785(TUBA3)(-)Loci: 2749 47975175-47978747 ~-4K 8788(PRPH)(+)Loci: 2750 48219206-48238344 ~-19K 8796(KCNH3)(+)Loci: 4031 48546946-48583987 ~-37K 8814(FAIM2)(-)Loci: 2751 48630795-48638929 ~-8K 8815(AQP2)(+)Loci: 2752 48737753-48763660 ~-26K 8820(ACCN2)(+)Loci: 2748 47658502-47662746 ~-4K 8771(WNT1)(+)Link out to UCSC