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0APOE_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAPOE
DescriptionApolipoprotein e precursor (apo-e).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005576 extracellular region (TAS)
0016209 antioxidant activity (NAS)
0050749 apolipoprotein E receptor binding (NAS)
0001540 beta-amyloid binding (IDA)
0008201 heparin binding (NAS)
0048156 tau protein binding (TAS)
0042632 cholesterol homeostasis (TAS)
0008015 circulation (NAS)
0007010 cytoskeleton organization and biogenesis (TAS)
0006917 induction of apoptosis (IDA)
0046907 intracellular transport (TAS)
0007611 learning and/or memory (TAS)
0006869 lipid transport (TAS)
0042157 lipoprotein metabolism (NAS)
0030516 regulation of axon extension (TAS)
0048168 regulation of neuronal synaptic plasticity (TAS)
0000302 response to reactive oxygen species (NAS)
0007271 synaptic transmission, cholinergic (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Exchangeable apolipoproteins (apoA.poC and apoE) have the same genomic structure and are members of a multi-gene family that probably evolved from a common ancestral gene. This entry includes the ApoA1.poA4 and ApoE proteins. ApoA1 and ApoA4 are part of the APOA1/C3/A4/A5 gene cluster on chromosome 11 . Apolipoproteins function in lipid transport as structural components of lipoprotein particles.ofactors for enzymes and ligands for cell-surface receptors. In particular.poA1 is the major protein component of high-density lipoproteins; apoA4 is thought to act primarily in intestinal lipid absorption; and apoE is a blood plasma protein that mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors.ncluding the low-density lipoprotein (LDL) receptor. Recent findings with apoA1 and apoE suggest that the tertiary structures of these two members of the human exchangeable apolipoprotein gene family are related . The three-dimensional structure of the LDL receptor-binding domain of apoE indicates that the protein forms an unusually elongated four-helix bundle that may be stabilized by a tightly packed hydrophobic core that includes leucine zipper-type interactions and by numerous salt bridges on the mostly charged surface. Basic amino acids important for LDL receptor binding are clustered into a surface patch on one long helix .
  IPR000074:Apolipoprotein A1/A4/E
This entry represents the 4-helical apolipoproteins (such as ApoA1.poA4 and ApoE) and the 5-helical apolipophorin. These exchangeable lipoproteins are thought to be structurally related . Apolipoproteins function in lipid transport as structural components of lipoprotein particles.ofactors for enzymes and ligands for cell-surface receptors.
  IPR013326:Apolipoprotein/apolipophorin
IPR000074:Apolipoprotein 
Evalue:-119.431800842285 
Location:80-304
SequencesProtein: APOE_HUMAN (317 aa)
mRNA: NM_000041
Local Annotation
Synapse Ontology
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
sdb:0035 regulation of synaptic plasticity  (Evidence:keywords)
The directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
sdb:0057 axon transport  (Evidence:keywords)
?
sdb:0247 cytoskeleton protein transport  (Evidence:keywords)
KO assignmentK04524
  Level 3 annotation:
    apolipoprotein E
  Level 2 annotation:
    Alzheimer's disease
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 21 residues, 50100878-50100938Exon2: 24 residues, 50101698-50101764Exon3: 66 residues, 50102856-50103049Exon4: 288 residues, 50103629-50104489Exon5: 2 residues, -Jump to APOE_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3116 50100878-50104489 ~-4K 19057(APOE)(+)Loci: 3117 50234137-50266053 ~-32K 19065(SFRS16)(+)Loci: 4398 50407718-50429309 ~-22K 19076(-)Loci: 3118 50446389-50500381 ~-54K 19078(MARK4)(+)Loci: 4399 50546685-50565669 ~-19K 19089(ERCC2)(-)Loci: 4400 50747641-50779917 ~-32K 19109(OPA3)(-)Loci: 4401 50804499-50834509 ~-30K 19111(EML2)(-)Loci: 3119 50863341-50877557 ~-14K 19113(GIPR)(+)Loci: 4402 51134630-51168497 ~-34K 19134(NOVA2)(-)Loci: 3120 51542133-51585943 ~-44K 19149(PPP5C)(+)Loci: 3121 51796351-51805878 ~-10K 19157(CALM1)(+)Loci: 4403 51869413-51911506 ~-42K 19161(PRKD2)(-)Loci: 4404 52033262-52046043 ~-13K 19167(AP2S1)(-)Loci: 3115 50004177-50016517 ~-12K 19053(LU)(+)Link out to UCSC