SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0APOB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAPOB
DescriptionApolipoprotein b-100 precursor (apo b-100) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005783 endoplasmic reticulum (NAS)
0005576 extracellular region (NAS)
0005792 microsome (TAS)
0005319 lipid transporter activity (NAS)
0005102 receptor binding (NAS)
0008015 circulation (NAS)
0006869 lipid transport (NAS)
0007165 signal transduction (NAS)

Warning: fopen(/home/kongl/syndb/www/temp/1523298040.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family contains regions from vitellogenin.icrosomal triglyceride transfer protein and apolipoprotein B-100. These proteins are all involved in lipid transport . This family contains the LV1n chain from lipovitellin.he predominantlipoprotein found in the yolk of egg-laying animals involved in lipid and metal storage. LV1n forms two domains and portions of two more:the N-sheet.he helical segment.ne beta-strand of the A-sheet.nd all but two beta-strands of the C-sheet. The N-sheet domain mainly consists of 11 beta-strands wrapped around an uncharged helix of 14 residues.lthough another beta-strand and 3 more small helicesare included. There are two disulphide bonds within this region; one is conserved in thehomologous proteins MTP and apoB. A drawn out loop containing two beta-strands helps to link the N-sheet to both the C- and A-sheets. In addition.depression in the N-sheet globular domain accepts the loops of several beta-strands from the C- and A-sheets forming multiple interactions. Past comments havesuggested the region has the appearance of and may function as a flexible "ball-and-socket" joint accommodating the lipid as the lipoprotein assembles .
  IPR001747:Lipid transport protein, N-terminal
This region is found in Apolipophorin proteins.
  IPR009454:Protein of unknown function DUF1081
Lipovitellin is the predominant lipoprotein found in the yolk of egg-laying animals and is involved in lipid and metal storage; it is formed from the precursor vitellogenin . Lipovitellin contains a heterogeneous mixture of about 16% (w/w) noncovalently bound lipid.ost being phospholipid. The superhelical domain within lipovitellin is multihelical.orming two curved.lpha/alpha layers with an overall right-handed superhelix fold.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011030:Lipovitellin, superhelical
IPR001747:Vitellogenin_N 
Evalue:-139.744720458984 
Location:46-598IPR009454:DUF1081 
Evalue:-55.7695503234863 
Location:957-1072IPR011030:LV_superhelical 
Evalue:0 
Location:4442-4468
SequencesProtein: APOB_HUMAN (4563 aa)
mRNA: NM_000384 X04714
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 636 residues, 21077806-21079711Exon2: 63 residues, 21080645-21080829Exon3: 40 residues, 21080937-21081052Exon4: 2526 residues, 21081456-21089028Exon5: 126 residues, 21089536-21089910Exon6: 50 residues, 21090824-21090970Exon7: 64 residues, 21091449-21091637Exon8: 60 residues, 21091746-21091922Exon9: 72 residues, 21092815-21093026Exon10: 42 residues, 21095368-21095490Exon11: 63 residues, 21096099-21096282Exon12: 72 residues, 21099207-21099419Exon13: 58 residues, 21099901-21100069Exon14: 66 residues, 21101309-21101501Exon15: 61 residues, 21103164-21103341Exon16: 81 residues, 21104204-21104442Exon17: 72 residues, 21104703-21104915Exon18: 51 residues, 21106015-21106162Exon19: 41 residues, 21106274-21106392Exon20: 78 residues, 21108730-21108958Exon21: 75 residues, 21109675-21109895Exon22: 30 residues, 21111192-21111278Exon23: 43 residues, 21111960-21112085Exon24: 54 residues, 21113476-21113632Exon25: 53 residues, 21114334-21114488Exon26: 50 residues, 21117314-21117460Exon27: 40 residues, 21118737-21118853Exon28: 15 residues, 21119889-21119928Exon29: 15 residues, 21120240-21120280Exon30: 55 residues, 21120289-21120450Exon31: 2 residues, -Jump to APOB_HUMANExon1: 636 residues, 21077806-21079711Exon2: 63 residues, 21080645-21080829Exon3: 40 residues, 21080937-21081052Exon4: 2526 residues, 21081456-21089028Exon5: 126 residues, 21089536-21089910Exon6: 50 residues, 21090824-21090970Exon7: 64 residues, 21091449-21091637Exon8: 60 residues, 21091746-21091922Exon9: 72 residues, 21092815-21093026Exon10: 42 residues, 21095368-21095490Exon11: 63 residues, 21096099-21096282Exon12: 72 residues, 21099207-21099419Exon13: 58 residues, 21099901-21100069Exon14: 66 residues, 21101309-21101501Exon15: 61 residues, 21103164-21103341Exon16: 81 residues, 21104204-21104442Exon17: 72 residues, 21104703-21104915Exon18: 51 residues, 21106015-21106162Exon19: 41 residues, 21106274-21106392Exon20: 78 residues, 21108730-21108958Exon21: 75 residues, 21109675-21109895Exon22: 30 residues, 21111192-21111278Exon23: 43 residues, 21111960-21112085Exon24: 54 residues, 21113476-21113632Exon25: 53 residues, 21114334-21114488Exon26: 50 residues, 21117314-21117460Exon27: 40 residues, 21118737-21118853Exon28: 15 residues, 21119889-21119928Exon29: 72 residues, 21120240-21120450Exon30: 2 residues, -Jump to APOB_HUMAN  
Tune and view alternative isoforms