SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0APOA2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAPOA2
DescriptionApolipoprotein a-ii precursor (apo-aii) (apoa-ii) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005576 extracellular region (NAS)
0005319 lipid transporter activity (NAS)
0046982 protein heterodimerization activity (IPI)
0042803 protein homodimerization activity (NAS)
0006006 glucose metabolism (TAS)
0006869 lipid transport (NAS)
0050995 negative regulation of lipid catabolism (NAS)
0050748 negative regulation of lipoprotein metabolism (NAS)
0042119 neutrophil activation (NAS)
0045416 positive regulation of interleukin-8 biosyn... (IDA)
0001817 regulation of cytokine production (NAS)
0009749 response to glucose stimulus (NAS)

Warning: fopen(/home/kongl/syndb/www/temp/195053748.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Apolipoprotein A-II (ApoA-II) is the second major apolipoprotein of high density lipoprotein in human plasma. Mature ApoA-II is present as a dimer of two 77-amino acid chains joined by a disulphide bridge . ApoA-II regulates many steps in HDL metabolism.nd its role in coronary heart disease is unclear . In bovine serum.he ApoA-II homologue is present in almost free form. Bovine ApoA-II shows antimicrobial activity against Escherichia coli and yeasts in phosphate buffered saline (PBS) .
  IPR006801:Apolipoprotein A-II (ApoA-II)
This entry represents the 4-helical apolipoproteins (such as ApoA1.poA4 and ApoE) and the 5-helical apolipophorin. These exchangeable lipoproteins are thought to be structurally related . Apolipoproteins function in lipid transport as structural components of lipoprotein particles.ofactors for enzymes and ligands for cell-surface receptors.
  IPR013326:Apolipoprotein/apolipophorin
IPR006801:ApoA-II 
Evalue:-52.7958793640137 
Location:24-100
SequencesProtein: APOA2_HUMAN (100 aa)
mRNA: NM_001643
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 77 residues, 159458706-159458936Exon2: 46 residues, 159459331-159459464Exon3: 27 residues, 159459763-159459839Exon4: 13 residues, 159460008-159460042Exon5: 2 residues, -Jump to APOA2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2566 159402817-159407634 ~-5K 3130(PPOX)(+)Loci: 3843 159407724-159413938 ~-6K 3131(B4GALT3)(-)Loci: 2567 159435728-159450806 ~-15K 3135(NDUFS2)(+)Loci: 3844 159458706-159460042 ~-1K 3139(APOA2)(-)Loci: 3845 159541150-159546368 ~-5K 3155(MPZ)(-)Loci: 2568 159550789-159601157 ~-50K 3157(SDHC)(+)Loci: 2565 159354514-159357481 ~-3K 3121(NIT1)(+)Link out to UCSC