SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0APOA1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAPOA1
DescriptionApolipoprotein a-i precursor (apo-ai) (apoa-i) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005576 extracellular region (NAS)
0008035 high-density lipoprotein binding (TAS)
0008203 cholesterol metabolism (TAS)
0008015 circulation (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/1442285597.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Exchangeable apolipoproteins (apoA.poC and apoE) have the same genomic structure and are members of a multi-gene family that probably evolved from a common ancestral gene. This entry includes the ApoA1.poA4 and ApoE proteins. ApoA1 and ApoA4 are part of the APOA1/C3/A4/A5 gene cluster on chromosome 11 . Apolipoproteins function in lipid transport as structural components of lipoprotein particles.ofactors for enzymes and ligands for cell-surface receptors. In particular.poA1 is the major protein component of high-density lipoproteins; apoA4 is thought to act primarily in intestinal lipid absorption; and apoE is a blood plasma protein that mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors.ncluding the low-density lipoprotein (LDL) receptor. Recent findings with apoA1 and apoE suggest that the tertiary structures of these two members of the human exchangeable apolipoprotein gene family are related . The three-dimensional structure of the LDL receptor-binding domain of apoE indicates that the protein forms an unusually elongated four-helix bundle that may be stabilized by a tightly packed hydrophobic core that includes leucine zipper-type interactions and by numerous salt bridges on the mostly charged surface. Basic amino acids important for LDL receptor binding are clustered into a surface patch on one long helix .
  IPR000074:Apolipoprotein A1/A4/E
This entry represents the 4-helical apolipoproteins (such as ApoA1.poA4 and ApoE) and the 5-helical apolipophorin. These exchangeable lipoproteins are thought to be structurally related . Apolipoproteins function in lipid transport as structural components of lipoprotein particles.ofactors for enzymes and ligands for cell-surface receptors.
  IPR013326:Apolipoprotein/apolipophorin
IPR000074:Apolipoprotein 
Evalue:-96.1611480712891 
Location:68-263
SequencesProtein: APOA1_HUMAN (267 aa)
mRNA: NM_000039
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 7 residues, 13497-13515Exon2: 23 residues, 13712-13775Exon3: 54 residues, 13962-14119Exon4: 221 residues, 14708-15367Exon5: 2 residues, -Jump to APOA1_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 220 residues, 116211678-116212337Exon2: 54 residues, 116212926-116213083Exon3: 23 residues, 116213270-116213333Exon4: 8 residues, 116213530-116213548Exon5: 2 residues, -Jump to APOA1_HUMAN  
Loci Cluster (Details)Loci: 3995 116661626-116692182 ~-31K 7822(BACE1)(-)Loci: 3994 116211678-116213548 ~-2K 7809(APOA1)(-)Link out to UCSC