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0APLP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAPLP1
DescriptionAmyloid-like protein 1 precursor (aplp) (aplp-1) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005604 basement membrane (TAS)
0005515 protein binding (IPI)
0007399 neurogenesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Amyloidogenic glycoprotein (A4 protein or APP) is an integral.lycosylated membrane brain protein . APP is associated with Alzheimers disease (AD). This responsibility stems from the fact that a small peptide (of 43 residues).alled the amyloid beta protein.hich is part of the sequence of A4.s the major constituent of amyloid deposits in AD and in Downs syndrome. As shown in the schematic representation below.he amyloid beta protein both precedes and forms part of the unique transmembrane region of A4.The exact function of A4 protein is not yet known.ut it has been suggested that it mediates cell-cell interactions .
  IPR008154:Amyloid A4 extracellular region
Amyloidogenic glycoprotein (A4 protein or APP) is an integral.lycosylated membrane brain protein . APP is associated with Alzheimers disease (AD). This responsibility stems from the fact that a small peptide (of 43 residues).alled the amyloid beta protein.hich is part of the sequence of A4.s the major constituent of amyloid deposits in AD and in Downs syndrome. As shown in the schematic representation below.he amyloid beta protein both precedes and forms part of the unique transmembrane region of A4.The exact function of A4 protein is not yet known.ut it has been suggested that it mediates cell-cell interactions .
  IPR008155:Amyloidogenic glycoprotein
IPR008154:A4_EXTRA 
Evalue:-121.602058410645 
Location:46-211IPR008155:AMYLOIDA4 
Evalue:0 
Location:579-604IPR008155:AMYLOIDA4 
Evalue:0 
Location:301-324IPR008155:AMYLOIDA4 
Evalue:0 
Location:626-648
SequencesProtein: APLP1_HUMAN (650 aa)
mRNA: NM_001024807 NM_005166
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords)
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
all the components of the clathrin coat, major ones are clathrin and clathrin adaptors.
sdb:0261 clathrin coat component  (Evidence:keywords)
?
sdb:0334 inhibitory postsynapstic component  (Evidence:keywords)
KO assignmentK05639
  Level 3 annotation:
    amyloid beta (A4) precursor-like protein 1
  Level 2 annotation:
    Prion disease
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 96 residues, 41051240-41051525Exon2: 50 residues, 41052408-41052552Exon3: 46 residues, 41053637-41053770Exon4: 39 residues, 41053978-41054091Exon5: 46 residues, 41054353-41054487Exon6: 61 residues, 41054599-41054778Exon7: 45 residues, 41055224-41055355Exon8: 27 residues, 41056380-41056455Exon9: 55 residues, 41057245-41057404Exon10: 45 residues, 41057482-41057611Exon11: 35 residues, 41059258-41059358Exon12: 38 residues, 41060459-41060567Exon13: 11 residues, 41060823-41060850Exon14: 25 residues, 41061325-41061396Exon15: 23 residues, 41061631-41061694Exon16: 50 residues, 41061815-41061959Exon17: 153 residues, 41062084-41062538Exon18: 2 residues, -Jump to APLP1_HUMANExon1: 96 residues, 41051240-41051525Exon2: 50 residues, 41052408-41052552Exon3: 46 residues, 41053637-41053770Exon4: 39 residues, 41053978-41054091Exon5: 46 residues, 41054353-41054487Exon6: 61 residues, 41054599-41054778Exon7: 45 residues, 41055224-41055355Exon8: 27 residues, 41056380-41056455Exon9: 55 residues, 41057245-41057404Exon10: 45 residues, 41057482-41057611Exon11: 35 residues, 41059258-41059358Exon12: 38 residues, 41060459-41060567Exon13: 10 residues, 41060826-41060850Exon14: 25 residues, 41061325-41061396Exon15: 23 residues, 41061631-41061694Exon16: 50 residues, 41061815-41061959Exon17: 153 residues, 41062084-41062538Exon18: 2 residues, -Jump to APLP1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3105 41051240-41062538 ~-11K 18643(APLP1)(+)Loci: 3106 41297727-41308689 ~-11K 18664(CKAP1)(+)Loci: 4386 41008705-41034579 ~-26K 18639(NPHS1)(-)Link out to UCSC