SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0APEX1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAPEX1
DescriptionDna-(apurinic or apyrimidinic site) lyase (ec 4.2.99.18) (ap endonuclease 1) (apex nuclease) (apen) (ref-1 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005783 endoplasmic reticulum (TAS)
0005634 nucleus (IDA)
0048471 perinuclear region (IDA)
0005840 ribosome (TAS)
0008408 3'-5' exonuclease activity (TAS)
0003677 DNA binding (IDA)
0003906 DNA-(apurinic or apyrimidinic site) lyase a... (TAS)
0004520 endodeoxyribonuclease activity (TAS)
0046872 metal ion binding (IDA)
0016491 oxidoreductase activity (IDA)
0004528 phosphodiesterase I activity (TAS)
0005515 protein binding (IPI)
0004523 ribonuclease H activity (TAS)
0003713 transcription coactivator activity (IDA)
0003714 transcription corepressor activity (TAS)
0004844 uracil DNA N-glycosylase activity (TAS)
0006284 base-excision repair (TAS)
0051101 regulation of DNA binding (IDA)
0006366 transcription from RNA polymerase II promoter (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/1647045650.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling . Proteins this domain is found in include: AP endonuclease proteins ().Nase I proteins ().ynaptojanin an inositol-1..-trisphosphate phosphatase () and Sphingomyelinase ().
  IPR005135:Endonuclease/exonuclease/phosphatase
DNA damaging agents such as the antitumor drugs bleomycin and neocarzinostatinor those that generate oxygen radicals produce a variety of lesions in DNA.Amongst these is base-loss which forms apurinic/apyrimidinic (AP) sites orstrand breaks with atypical 3termini. DNA repair at the AP sites is initiatedby specific endonuclease cleavage of the phosphodiester backbone. Suchendonucleases are also generally capable of removing blocking groups from the3terminus of DNA strand breaks.AP endonucleases can be classified into two families on the basis of sequencesimilarity. This family contains members of AP endonuclease family 1.Except for Rrp1 and arp.hese enzymes are proteins of about 300 amino-acidresidues. Rrp1 and arp both contain additional and unrelated sequences intheir N-terminal section (about 400 residues for Rrp1 and 270 for arp).The proteins containglutamate which has been shown .n the Escherichia coli enzyme to bind adivalent metal ion such as magnesium or manganese.
  IPR000097:AP endonuclease, family 1
All proteins in this family for which functions are known are 5 AP endonucleases that function in base excision repair and the repair of abasic sites in DNA.
  IPR004808:Exodeoxyribonuclease III xth
IPR005135:Exo_endo_phos 
Evalue:-62.0457572937012 
Location:61-315
SequencesProtein: APEX1_HUMAN (317 aa)
mRNA: NM_001641
Local Annotation
Synapse Ontology
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentK01741
  Level 3 annotation:
    DNA-(apurinic or apyrimidinic site) lyase
  Level 2 annotation:
    Other replication
     recombination and repair proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 89 residues, 19993129-19993393Exon2: 44 residues, 19993576-19993702Exon3: 64 residues, 19993912-19994100Exon4: 66 residues, 19994666-19994859Exon5: 260 residues, 19994989-19995765Exon6: 2 residues, -Jump to APEX1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2822 19598043-19598982 ~-1K 10739(OR4L1)(+)Loci: 4110 19849367-19871297 ~-22K 10743(CCNB1IP1)(-)Loci: 4111 19905765-19951420 ~-46K 10749(TEP1)(-)Loci: 4112 19985056-19993038 ~-8K 10750(OSGEP)(-)Loci: 2823 19993129-19995765 ~-3K 10751(APEX1)(+)Loci: 2821 19414266-19415211 ~-1K 10737(OR4K2)(+)Link out to UCSC