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0APC_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAPC
DescriptionAdenomatous polyposis coli protein (apc protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008013 beta-catenin binding (TAS)
0007155 cell adhesion (TAS)
0006461 protein complex assembly (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules .
  IPR009234:APC basic
This region at the C terminus of the APC proteins binds the microtubule-associating protein EB-1 . At the C terminus of the alignment is also a PDZ-binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins (e.g. ).
  IPR009232:EB-1 binding
This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin .
  IPR009223:APC cysteine-rich
This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin .
  IPR009224:SAMP
The 15 aa repeat is found in the APC protein family. It is involved in binding beta-catenin along with the repeats. Many human cancer mutations map to the region around these motifs.nd may be involved in disrupting their binding of beta-catenin.
  IPR009240:APC 15 residue
The armadillo (Arm) repeat is an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila melanogaster segment polarity gene armadillo involved in signal transduction through wingless. Animal Arm-repeat proteins function in various processes.ncluding intracellular signalling and cytoskeletal regulation.nd include such proteins as beta-catenin.he junctional plaque protein plakoglobin.he adenomatous polyposis coli (APC) tumour suppressor protein.nd the nuclear transport factor importin-alpha.mongst others . A subset of these proteins is conserved across eukaryotic kingdoms. In higher plants.ome Arm-repeat proteins function in intracellular signalling like their mammalian counterparts.hile others have novel functions .The 3-dimensional fold of an armadillo repeat is known from the crystal structure of beta-catenin.here the 12 repeats form a superhelix of alpha helices with three helices per unit . The cylindrical structure features a positively charged grove.hich presumably interacts with the acidic surfaces of the known interaction partners of beta-catenin.
  IPR000225:Armadillo
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix.here the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
IPR009234:APC_basic 
Evalue:-1e+125 
Location:2220-2579IPR009232:EB1_binding 
Evalue:-83.5850296020508 
Location:2670-2843IPR009223:APC_crr 
Evalue:-10.2076082229614 
Location:1256-1281IPR000225:Arm 
Evalue:-9.65757751464844 
Location:649-689IPR009224:SAMP 
Evalue:-9.30103015899658 
Location:1568-1589IPR009224:SAMP 
Evalue:-9.25963687896728 
Location:1718-1738IPR009224:SAMP 
Evalue:-8.61978912353516 
Location:2033-2053IPR009223:APC_crr 
Evalue:-7.85387182235718 
Location:1636-1661IPR009223:APC_crr 
Evalue:-7.56863641738892 
Location:2006-2031IPR009223:APC_crr 
Evalue:-7.03151702880859 
Location:1369-1394IPR009223:APC_crr 
Evalue:-6.85387182235718 
Location:1948-1973IPR009223:APC_crr 
Evalue:-6.46852111816406 
Location:1840-1866IPR009223:APC_crr 
Evalue:-6.13076829910278 
Location:1485-1510IPR009240:APC_15aa 
Evalue:-5.48148584365845 
Location:1172-1187IPR009240:APC_15aa 
Evalue:-5.44369745254517 
Location:1020-1035IPR009240:APC_15aa 
Evalue:-5.07058095932007 
Location:1155-1170IPR000225:Arm 
Evalue:-4.95860719680786 
Location:691-731IPR000225:Arm 
Evalue:-4.82390880584717 
Location:512-553IPR009240:APC_15aa 
Evalue:-4.39794015884399 
Location:1136-1151IPR000225:ARM 
Evalue:-4.20065945054642 
Location:340-392IPR000225:Arm 
Evalue:-3.46852111816406 
Location:556-597IPR000225:ARM 
Evalue:-3.18708664335714 
Location:459-510IPR000225:ARM 
Evalue:1.76342799356294 
Location:599-644
SequencesProtein: APC_HUMAN (2843 aa)
mRNA: NM_000038
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
KO assignmentK02085
  Level 3 annotation:
    adenomatosis polyposis coli
  Level 2 annotation:
    Wnt signaling pathway
    Regulation of actin cytoskeleton
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 14 residues, 112101482-112101521Exon2: 53 residues, 112118468-112118621Exon3: 30 residues, 112129921-112130006Exon4: 69 residues, 112130784-112130986Exon5: 38 residues, 112139224-112139333Exon6: 40 residues, 112144385-112144499Exon7: 30 residues, 112156041-112156125Exon8: 37 residues, 112164874-112164979Exon9: 35 residues, 112179090-112179189Exon10: 128 residues, 112182561-112182940Exon11: 34 residues, 112185491-112185587Exon12: 48 residues, 112190703-112190843Exon13: 28 residues, 112191524-112191602Exon14: 41 residues, 112192451-112192568Exon15: 73 residues, 112198546-112198761Exon16: 2897 residues, 112201148-112209834Exon17: 2 residues, -Jump to APC_HUMAN  
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