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0AP4S1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionAdapter-related protein complex 4 sigma 1 subunit (sigma subunit of ap-4) (ap-4 adapter complex sigma subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005215 transporter activity (TAS)
Domain Architecture (Details)
InterPro domains assigned to SynO:
VAMPs (and its homologue synaptobrevins) define a group of SNARE proteins that contain a C-terminal coiled-coil/SNARE motif.n combination with variable N-terminal domains that are used to classify VAMPs: those containing longin N-terminal domains (~150 aa) are referred to as longins.hile those with shorter N-termini are referred to as brevins . Longins are the only type of VAMP protein found in all eukaryotes.uggesting that their longin domain is essential. The longin domain is thought to exert a regulatory function. Longin domains have been shown to share the same structural fold. profilin-like globular domain consisting of a five-stranded antiparallel beta-sheet that is sandwiched by an alpha-helix on one side.nd two alpha-helices on the other (beta(2)-alpha-beta(3)-alpha(2)).Other families have been shown to contain domains that structurally resemble the VAMP longin domain. An example is the eukaryotic conserved protein.EDL.hich is a component of the transport protein particle (TRAPP).ritically involved in endoplasmic reticulum-to-Golgi vesicle transport; mutations in the SEDL gene are associated with an X-linked skeletal disorder.pondyloepiphyseal dysplasia tarda . Another example is the assembly domain of clathrin coat proteins.uch as Mu2 adaptin (AP50) and Sigma2 adaptin (AP17).hich structurally resemble the longin domain. AP50 and AP17 are two of the proteins that make up the core of AP2. complex that functions in clathrin-mediated endocytosis .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
InterPro domains unassigned to SynO:
Clathrin coated vesicles (CCV) mediate intracellular membrane traffic such as receptor mediated endocytosis. In addition to clathrin.he CCV are composed of a number of other components including oligomeric complexes which are known as adaptor or clathrin assembly proteins (AP) complexes . The adaptor complexes are believed to interact with the cytoplasmic tails of membrane proteins.eading to their selection and concentration. In mammals two type of adaptor complexes are known.P-1 which is associated with the Golgi complex and AP-2 which is associated with the plasma membrane. Both AP-1 and AP-2 are heterotetramers that consist of two large chains.he adaptins.gamma and beta in AP-1; alpha and beta in AP-2); a medium chain (AP47 in AP-1; AP50 in AP-2) and a small chain (AP19 in AP-1; AP17 in AP-2). The small chains of AP-1 and AP-2 are evolutionary related proteins of about 18 kD. Homologs of AP17 and AP19 have also been found in yeast (genes APS1/YAP19 and APS2/YAP17) . AP17 and AP19 are also related to the zeta-chain of coatomer (zeta-cop). cytosolic protein complex that reversibly associates with Golgi membranes to form vesicles that mediate biosynthetic protein transport from the endoplasmic reticulum.ia the Golgi up to the trans Golgi network. Some members of this family are part of the AP-3 complex.n adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole.
  IPR000804:Clathrin adaptor complex, small chain
SequencesProtein: AP4S1_HUMAN (144 aa)
mRNA: BC035622
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
Fusion of intracellular membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
sdb:0049 synaptic vesicle fusion  (Evidence:keywords,domains)
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 41 residues, 30564624-30564744Exon2: 71 residues, 30605082-30605291Exon3: 31 residues, 30608799-30608886Exon4: 25 residues, 30611861-30611930Exon5: 26 residues, 30619529-30619601Exon6: 42 residues, 30622482-30622604Exon7: 149 residues, 30623725-30624168Exon8: 2 residues, -Jump to Q86U36_HUMANExon1: 34 residues, 30564643-30564744Exon2: 71 residues, 30605082-30605291Exon3: 31 residues, 30608799-30608886Exon4: 25 residues, 30611861-30611930Exon5: 26 residues, 30619529-30619601Exon6: 346 residues, 30623725-30624758Exon7: 2 residues, -Jump to Q9BVE7_HUMANExon1: 226 residues, 30565599-30566274Exon2: 71 residues, 30605082-30605291Exon3: 31 residues, 30608799-30608886Exon4: 25 residues, 30611861-30611930Exon5: 6 residues, 30619529-30619541Exon6: 176 residues, 30631863-30632385Exon7: 2 residues, -Jump to AP4S1_HUMAN  
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Loci Cluster (Details)Loci: 2829 30564624-30632385 ~-68K 10990(+)Loci: 2828 30161271-30274769 ~-113K 10985(SCFD1)(+)Link out to UCSC