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0AP4B1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAP4B1
DescriptionAdapter-related protein complex 4 beta 1 subunit (beta subunit of ap- 4) (ap-4 adapter complex beta subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005802 Golgi trans face (TAS)
0005625 soluble fraction (TAS)
0005215 transporter activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is the N-terminal region of various alpha.eta and gamma subunits of the AP-1.P-2 and AP-3 adaptorprotein complexes. The adaptor protein (AP) complexes are involved inthe formation of clathrin-coated pits and vesicles .The N-terminal region of the various adaptor proteins (APs) is constantby comparison to the C-terminal which is variable within members of theAP-2 family ; and it has been proposed that this constant regioninteracts with another uniform component of the coated vesicles .
  IPR002553:Adaptin, N-terminal
The AP2 adaptor is a heterotetramer that plays a central role in clathrin-mediated endocytosis by linking transmembrane receptors to be internalised to the clathrin lattice. During clathrin-mediated endocytosis.lathrin-coated vesicles are formed by pinching off a portion of the plasma membrane.long with its cargo molecules. The AP2 adaptor links the cargo to the clathrin coat.nd can interact with proteins involved in the formation of the clathrin-coated vesicles. The AP2 adaptor is composed of four subunits.f which alpha and beta2 are the largest. The alpha and beta2 adaptor subunits can each be divided into a trunk domain and the appendage domain (or ear domain).eparated by a linker region. Clathrin polymerisation is promoted by its binding to the beta2 appendage and hinge domains. The alpha appendage domain interacts with a number of accessory proteins.ncluding eps15.psin.mphiphysin.P180.uxilin.umb.nd Dab2.hereby regulating the translocation of these proteins to the bud site. The appendage domains of the alpha and beta2 subunits are structurally similar . The structure of this domain consists of a three-layer arrangement.lpha-beta-alpha.ith a bifurcated antiparallel beta-sheet. COP-I coatomer subunits.hich function in vesicle coat assembly.how a weak sequence similarity to the AP2 clathrin adaptor .
  IPR009028:AP2 clathrin adaptor, alpha and beta chain, appendage
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix.here the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
The TATA-box binding protein (TBP) is required for the initiation of transcription by RNA polymerases I.I and III.rom promoters with or without a TATA box . TBP associates with a host of factors.ncluding the general transcription factors TFIIA.B.D.E.nd -H.o form huge multi-subunit pre-initiation complexes on the core promoter. Through its association with different transcription factors.BP can initiate transcription from different RNA polymerases. There are several related TBPs.ncluding TBP-like (TBPL) proteins . The C-terminal core of TBP (~180 residues) is highly conserved and contains two 77-amino acid repeats that produce a saddle-shaped structure that straddles the DNA; this region binds to the TATA box.nd interacts with transcription factors and regulatory proteins .The beta(2)-adaptor is one of four subunits that comprise the clathrin adaptor.hich plays a central role in clathrin-mediated endocytosis by linking transmembrane receptors to be internalised to the clathrin lattice. The C-terminal domain of beta(2)-adaptor is the appendage or ear domain.hich is involved in clathrin polymerisation.Even though the C-terminal of beta(2)-adaptin has a very low sequence identity with the C-terminal of the TATA-box binding protein.hey do share structural similarities.amely a beta-alpha-beta(4)-alpha core structure.
  IPR012295:Beta2-adaptin/TATA-box binding, C-terminal
IPR002553:Adaptin_N 
Evalue:-70.6989669799805 
Location:7-526IPR012295:bAdaptin_TBP_C 
Evalue:0 
Location:616-733
SequencesProtein: AP4B1_HUMAN (739 aa)
mRNA: NM_006594
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 146 residues, 114239200-114239637Exon2: 96 residues, 114239901-114240183Exon3: 71 residues, 114240402-114240610Exon4: 36 residues, 114241984-114242088Exon5: 30 residues, 114242862-114242946Exon6: 167 residues, 114244048-114244545Exon7: 51 residues, 114245380-114245528Exon8: 45 residues, 114245899-114246030Exon9: 77 residues, 114246782-114247007Exon10: 65 residues, 114248749-114248938Exon11: 45 residues, 114249086-114249215Exon12: 2 residues, -Jump to AP4B1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3822 114435911-114497995 ~-62K 2236(SYT6)(-)Loci: 3823 114911705-114925788 ~-14K 2241(BCAS2)(-)Loci: 3821 114239200-114249215 ~-10K 2227(AP4B1)(-)Link out to UCSC