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0AP1G2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAP1G2
DescriptionAdapter-related protein complex 1 gamma 2 subunit (gamma2-adaptin) (adaptor protein complex ap-1 gamma-2 subunit) (g2ad).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0030121 AP-1 adaptor complex (TAS)
0005798 Golgi vesicle (IDA)
0016020 membrane (IDA)
0030133 transport vesicle (IDA)
0005515 protein binding (ISS)
0016192 vesicle-mediated transport (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is the N-terminal region of various alpha.eta and gamma subunits of the AP-1.P-2 and AP-3 adaptorprotein complexes. The adaptor protein (AP) complexes are involved inthe formation of clathrin-coated pits and vesicles .The N-terminal region of the various adaptor proteins (APs) is constantby comparison to the C-terminal which is variable within members of theAP-2 family ; and it has been proposed that this constant regioninteracts with another uniform component of the coated vesicles .
  IPR002553:Adaptin, N-terminal
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins.eading to their selection and concentration. Gamma-adaptin is a subunit of the golgi adaptor. Alpha adaptin is a heterotetramer that regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This Ig-fold domain is found in alpha.eta and gamma adaptins and consists of a beta-sandwich containing 7 strands in 2 beta-sheets in a greek-key topology . The adaptor appendage contains an additional N-terminal strand.
  IPR008152:Alpha/gamma adaptin, C-terminal
The adaptor proteins AP-1 and GGA (Golgi-localized.amma ear-containing.DP-ribosylation factor (ARF)-binding proteins) regulate membrane traffic betweenthe trans-Golgi network (TGN) and endosome/lysosomes through ARF-regulatedmembrane association.ecognition of sorting signals.nd recruitment ofclathrin and accessory proteins . The gamma-adaptin ear (GAE) domain is a C-terminal appendage or ear of about 120 residues.hich is found in gamma-adaptins.he heavy subunits of the AP-1 complex.nd in GGAs. The GAE domain.hich is found in associated with other domains such as VHS.oiled-coils and GAT.s involved in the recruitment of accessory proteins.uch as gamma-synergin.ababptin-5.ps15 and cyclin G-associated kinase.hich modulate the functions of GAE domain containing proteins in the membranetrafficking events .The resolution of the 3D-structure of the human gamma-adaptin GAE domain showsthat it forms an immunoglobulin-like beta-sandwich fold composed of eightbeta-strands.ade up of a five-stranded beta-sheet and a three-stranded beta-sheet.ith two short alpha-helices. The topology ofthe entire GAE domain is similar to those of the N-terminal subdomains in thealpha- and beta-adaptin ear domains of the AP-2 complex. However.he GAEdomain has very low sequence identity and homology to the N-terminalimmunoglobulin-like subdomains of the alpha and beta ear domains. The bindingsite for the accessory proteins has been located to a shallow hydrophobictrough surrounded by charged (mainly basic) residues .
  IPR008153:Gamma-adaptin, C-terminal
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix.here the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
IPR002553:Adaptin_N 
Evalue:-221.823913574219 
Location:24-575IPR008152:Alpha_adaptinC2 
Evalue:-52.6197891235352 
Location:662-780
SequencesProtein: AP1G2_HUMAN (785 aa)
mRNA: NM_080545
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
all the components of the clathrin coat, major ones are clathrin and clathrin adaptors.
sdb:0261 clathrin coat component  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 95 residues, 23098616-23098899Exon2: 35 residues, 23098986-23099085Exon3: 56 residues, 23099303-23099467Exon4: 47 residues, 23100344-23100480Exon5: 43 residues, 23100560-23100684Exon6: 37 residues, 23101010-23101115Exon7: 44 residues, 23101336-23101464Exon8: 32 residues, 23101552-23101642Exon9: 43 residues, 23102428-23102551Exon10: 20 residues, 23102632-23102687Exon11: 49 residues, 23102764-23102905Exon12: 40 residues, 23103094-23103208Exon13: 20 residues, 23103381-23103437Exon14: 35 residues, 23103610-23103709Exon15: 29 residues, 23104167-23104248Exon16: 34 residues, 23104654-23104750Exon17: 27 residues, 23104864-23104941Exon18: 34 residues, 23105112-23105209Exon19: 49 residues, 23105326-23105468Exon20: 43 residues, 23105610-23105735Exon21: 322 residues, 23106159-23107119Exon22: 2 residues, -Jump to AP1G2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4116 22525950-22549192 ~-23K 10843(C14orf93)(-)Loci: 4117 22597615-22634663 ~-37K 10853(ACIN1)(-)Loci: 2824 22845875-22850798 ~-5K 10860(BCL2L2)(+)Loci: 2825 22859236-22865202 ~-6K 10861(PABPN1)(+)Loci: 4118 22895451-22904682 ~-9K 10864(EFS)(-)Loci: 4119 22921038-22947324 ~-26K 10871(MYH6)(-)Loci: 4120 22951789-22973312 ~-22K 10872(MYH7)(-)Loci: 4121 23059904-23065839 ~-6K 10876(ZFHX2)(-)Loci: 4122 23098616-23107119 ~-9K 10881(AP1G2)(-)Loci: 4115 22439745-22458214 ~-18K 10832(RBM23)(-)Link out to UCSC