SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0ANXA2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameANXA2
DescriptionAnnexin a2 (annexin ii) (lipocortin ii) (calpactin i heavy chain) (chromobindin-8) (p36) (protein i) (placental anticoagulant protein iv) (pap-iv).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005886 plasma membrane (TAS)
0005625 soluble fraction (TAS)
0004859 phospholipase inhibitor activity (TAS)
0001501 skeletal development (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/576208722.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
More than a thousand proteins of the annexin superfamily have been identified in major eukaryotic phyla.ut annexins are absent from yeasts and prokaryotes . Most eukaryotic species have 1-20 annexin (ANX) genes; even the primitive unicellular protist Giardia has at least seven. All annexins share a core domain made up of four similar repeats.ach approximately 70 amino acids long . Each repeat is made up of five alpha helices and usually contains a characteristic type 2 motif for binding calcium ions with the sequence GxGT-[38 residues]-D/E. Animal and fungal annexins also have variable amino-terminal domains. The core domains of most vertebrate annexins have been analyzed by X-ray crystallography.evealing conservation of their secondary and tertiary structures despite only 45-55% amino-acid identity among individual members. Each annexin repeat is folded into five alpha-helices.nd these in turn are wound into a right-handed super-helix. The four repeats pack into a structure that resembles a flattened disc.ith a slightly convex surface on which the Ca2+-binding loops are located and a concave surface at which the amino and carboxyl termini come into close apposition. Annexins are traditionally thought of as calcium-dependent phospholipid-binding proteins.ut recent work suggests a more complex set of functions.
  IPR001464:Annexin
More than a thousand proteins of the annexin superfamily have been identified in major eukaryotic phyla.ut annexins are absent from yeasts and prokaryotes . Most eukaryotic species have 1-20 annexin (ANX) genes; even the primitive unicellular protist Giardia has at least seven. All annexins share a core domain made up of four similar repeats.ach approximately 70 amino acids long . Each repeat is made up of five alpha helices and usually contains a characteristic type 2 motif for binding calcium ions with the sequence GxGT-[38 residues]-D/E. Animal and fungal annexins also have variable amino-terminal domains. The core domains of most vertebrate annexins have been analyzed by X-ray crystallography.evealing conservation of their secondary and tertiary structures despite only 45-55% amino-acid identity among individual members. Each annexin repeat is folded into five alpha-helices.nd these in turn are wound into a right-handed super-helix. The four repeats pack into a structure that resembles a flattened disc.ith a slightly convex surface on which the Ca2+-binding loops are located and a concave surface at which the amino and carboxyl termini come into close apposition. Annexins are traditionally thought of as calcium-dependent phospholipid-binding proteins.ut recent work suggests a more complex set of functions. Type II annexins bind two calcium ions and inhibit phospholipase A2.ollowing dephosphorylation by protein kinases involved in the signal transduction pathway. They may also cross-link plasma membrane phospholipids with actin and the cytoskeleton.nd possibly play a part in exocytosis.ince they are also involved in granule aggregation and membrane fusion.
  IPR002389:Annexin, type II
IPR001464:Annexin 
Evalue:-34.6989707946777 
Location:108-173IPR001464:Annexin 
Evalue:-28.1870861053467 
Location:268-333IPR001464:Annexin 
Evalue:-22.3767509460449 
Location:36-101IPR001464:Annexin 
Evalue:-17.8538722991943 
Location:192-258IPR002389:ANNEXINII 
Evalue:0 
Location:1-19IPR002389:ANNEXINII 
Evalue:0 
Location:20-31IPR002389:ANNEXINII 
Evalue:0 
Location:180-191
SequencesProtein: ANXA2_HUMAN (338 aa)
mRNA: NM_001002857 NM_001002858
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 180 residues, 58426643-58427180Exon2: 43 residues, 58428565-58428688Exon3: 21 residues, 58430683-58430742Exon4: 34 residues, 58431214-58431310Exon5: 33 residues, 58431873-58431967Exon6: 22 residues, 58433644-58433704Exon7: 28 residues, 58435409-58435489Exon8: 32 residues, 58436636-58436727Exon9: 40 residues, 58440431-58440545Exon10: 33 residues, 58443919-58444014Exon11: 35 residues, 58461832-58461932Exon12: 21 residues, 58465518-58465577Exon13: 29 residues, 58476748-58476829Exon14: 16 residues, 58477433-58477477Exon15: 2 residues, -Jump to ANXA2_HUMANExon1: 180 residues, 58426643-58427180Exon2: 43 residues, 58428565-58428688Exon3: 21 residues, 58430683-58430742Exon4: 34 residues, 58431214-58431310Exon5: 33 residues, 58431873-58431967Exon6: 22 residues, 58433644-58433704Exon7: 28 residues, 58435409-58435489Exon8: 32 residues, 58436636-58436727Exon9: 40 residues, 58440431-58440545Exon10: 33 residues, 58443919-58444014Exon11: 35 residues, 58461832-58461932Exon12: 21 residues, 58465518-58465577Exon13: 40 residues, 58477361-58477477Exon14: 2 residues, -Jump to ANXA2_HUMAN  
Tune and view alternative isoforms