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0ANFY1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameANKFY1
DescriptionAnkyrin repeat and fyve domain protein 1 (ankyrin repeats hooked to a zinc finger motif).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0010008 endosome membrane (ISS)
0006897 endocytosis (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The FYVE zinc finger is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. The FYVE finger has been shown to bind two Zn2+ ions . The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG.here + represents a charged residue and X any residue.
  IPR000306:Zinc finger, FYVE-type
The BTB (for BR-C.tk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N terminus of a fraction of zinc finger() proteins and in proteins that contain the motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation .The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule .POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT .The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
  IPR000210:BTB
The BTB (for BR-C.tk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N terminus of a fraction of zinc finger() proteins and in proteins that contain the motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation .The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule .POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT .The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
  IPR013069:BTB/POZ
The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers . The repeat has been found in proteins of diverse function such as transcriptional initiators.ell-cycle regulators.ytoskeletal.on transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it. The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures . Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure .
  IPR002110:Ankyrin
Zinc finger domains (ZnFs) are common.elatively small protein motifs that fold around one or more zinc ions. In addition to their role as a DNA-binding module.nFs have recently been shown to mediate protein:protein and protein:lipid interactions. There are at least 14 different classes of Zn fingers.hich differ in the nature and arrangement of their zinc-binding residues .The FYVE zinc finger domain is conserved from yeast to man.nd is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P).hich is found mainly on endosomes .The plant homeodomain (PHD) zinc finger domain has a C4HC3-type motif.nd is widely distributed in eukaryotes.eing found in many chromatin regulatory factors .Both the FYVE and the PHD zinc finger motifs display strikingly similar dimetal(zinc)-bound alpha+beta folds.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011011:Zinc finger, FYVE/PHD-type
IPR000306:FYVE 
Evalue:-25.5086383061657 
Location:1099-1165IPR000210:BTB 
Evalue:-18.602059991328 
Location:68-162IPR002110:Ank 
Evalue:-12 
Location:769-801IPR002110:Ank 
Evalue:-9.49485015869141 
Location:490-522IPR002110:Ank 
Evalue:-6.76955127716064 
Location:542-574IPR002110:Ank 
Evalue:-6.50863838195801 
Location:322-365IPR002110:Ank 
Evalue:-6.48148584365845 
Location:905-937IPR002110:Ank 
Evalue:-6.33724212646484 
Location:621-653IPR002110:Ank 
Evalue:-4.92081880569458 
Location:938-970IPR002110:Ank 
Evalue:-3.79588007926941 
Location:255-287IPR002110:Ank 
Evalue:-3.76955103874207 
Location:654-686IPR002110:Ank 
Evalue:-3.25963735580444 
Location:971-1004IPR002110:Ank 
Evalue:-3.24412512779236 
Location:802-835IPR002110:Ank 
Evalue:-3.19381999969482 
Location:1043-1075IPR002110:Ank 
Evalue:-2.95860719680786 
Location:366-399IPR002110:Ank 
Evalue:-2.50863838195801 
Location:870-902IPR002110:Ank 
Evalue:-2.46852111816406 
Location:288-320IPR002110:Ank 
Evalue:-1.76955103874207 
Location:687-713IPR002110:Ank 
Evalue:-1.6020599603653 
Location:724-756IPR002110:Ank 
Evalue:-1.31875872612 
Location:457-489IPR002110:Ank 
Evalue:-0.508638322353363 
Location:400-455IPR002110:Ank 
Evalue:0.431363761425018 
Location:588-620IPR002110:Ank 
Evalue:1 
Location:1005-1042IPR002110:ANK 
Evalue:2.8750612633917 
Location:836-865
SequencesProtein: ANFY1_HUMAN (1169 aa)
mRNA: BC060812 NM_016376
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
endosomal intermediate functions as a sorting station before be redirected into the recycling vesicle population.
sdb:0150 endosomal intermediate  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1336 residues, 4013949-4017954Exon2: 32 residues, 4019240-4019331Exon3: 51 residues, 4020757-4020904Exon4: 43 residues, 4022599-4022724Exon5: 32 residues, 4023397-4023488Exon6: 51 residues, 4023952-4024100Exon7: 61 residues, 4027169-4027346Exon8: 69 residues, 4028900-4029101Exon9: 54 residues, 4029764-4029921Exon10: 41 residues, 4031297-4031416Exon11: 58 residues, 4032224-4032393Exon12: 53 residues, 4033441-4033595Exon13: 35 residues, 4033855-4033954Exon14: 78 residues, 4034861-4035090Exon15: 34 residues, 4039425-4039523Exon16: 68 residues, 4045021-4045221Exon17: 25 residues, 4045446-4045515Exon18: 70 residues, 4047416-4047621Exon19: 57 residues, 4056364-4056530Exon20: 52 residues, 4057976-4058126Exon21: 43 residues, 4059867-4059991Exon22: 47 residues, 4067026-4067162Exon23: 41 residues, 4085815-4085934Exon24: 66 residues, 4092299-4092492Exon25: 10 residues, 4113975-4114000Exon26: 2 residues, -Jump to ANFY1_HUMANExon1: 547 residues, 4016316-4017954Exon2: 32 residues, 4019240-4019331Exon3: 51 residues, 4020757-4020904Exon4: 43 residues, 4022599-4022724Exon5: 32 residues, 4023397-4023488Exon6: 51 residues, 4023952-4024100Exon7: 61 residues, 4027169-4027346Exon8: 69 residues, 4028900-4029101Exon9: 54 residues, 4029764-4029921Exon10: 41 residues, 4031297-4031416Exon11: 59 residues, 4032224-4032396Exon12: 53 residues, 4033441-4033595Exon13: 35 residues, 4033855-4033954Exon14: 78 residues, 4034861-4035090Exon15: 34 residues, 4039425-4039523Exon16: 68 residues, 4045021-4045221Exon17: 25 residues, 4045446-4045515Exon18: 70 residues, 4047416-4047621Exon19: 57 residues, 4056364-4056530Exon20: 52 residues, 4057976-4058126Exon21: 43 residues, 4059867-4059991Exon22: 47 residues, 4067026-4067162Exon23: 41 residues, 4085815-4085934Exon24: 66 residues, 4092299-4092492Exon25: 10 residues, 4113975-4114000Exon26: 2 residues, -Jump to ANFY1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4249 2912712-2913651 ~-1K 14853(OR1D5)(-)Loci: 4250 2976653-2977595 ~-1K 14854(OR1G1)(-)Loci: 4251 3127934-3129018 ~-1K 14856(OR3A2)(-)Loci: 2967 3270617-3271577 ~-1K 14858(OR3A3)(+)Loci: 2968 3486764-3511581 ~-25K 14869(CTNS)(+)Loci: 2969 3573945-3576739 ~-3K 14877(GSG2)(+)Loci: 4252 3710373-3743086 ~-33K 14879(CAMKK1)(-)Loci: 4253 3773917-3814485 ~-41K 14884(ATP2A3)(-)Loci: 4254 4013949-4114000 ~-100K 14897(ANKFY1)(-)Loci: 2966 2443685-2535638 ~-92K 14848(PAFAH1B1)(+)Link out to UCSC