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0ANAG_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNAGLU
DescriptionAlpha-n-acetylglucosaminidase precursor (ec 3.2.1.50) (n-acetyl-alpha- glucosaminidase) (nag) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005764 lysosome (TAS)
0004561 alpha-N-acetylglucosaminidase activity (TAS)
0007399 neurogenesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Alpha-N-acetylglucosaminidase is a lysosomal enzyme required for the stepwise degradation of heparan sulphate . Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations .
  IPR007781:Alpha-N-acetylglucosaminidase
IPR007781:NAGLU 
Evalue:-1e+125 
Location:69-734
SequencesProtein: ANAG_HUMAN (743 aa)
mRNA: NM_000263
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK01205
  Level 3 annotation:
    alpha-N-acetylglucosaminidase
  Level 2 annotation:
    Glycosaminoglycan degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 242 residues, 37941476-37942199Exon2: 51 residues, 37942941-37943089Exon3: 51 residues, 37943882-37944029Exon4: 30 residues, 37944213-37944299Exon5: 87 residues, 37946493-37946750Exon6: 475 residues, 37948571-37949990Exon7: 2 residues, -Jump to ANAG_HUMAN  
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Loci Cluster (Details)Loci: 4288 37562438-37586822 ~-24K 15872(KCNH4)(-)Loci: 4289 37589603-37590996 ~-1K 15873(HCRT)(-)Loci: 3002 37864387-37928122 ~-64K 15882(ATP6V0A1)(+)Loci: 3003 37941476-37949990 ~-9K 15887(NAGLU)(+)Loci: 3004 38064836-38072549 ~-8K 15898(TUBG2)(+)Loci: 3005 38088157-38105358 ~-17K 15903(CNTNAP1)(+)Loci: 4290 38105819-38150574 ~-45K 15904(EZH1)(-)Loci: 3006 38186221-38202605 ~-16K 15907(WNK4)(+)Loci: 4291 38215677-38229807 ~-14K 15912(BECN1)(-)Loci: 3007 38250134-38256248 ~-6K 15916(AOC2)(+)Loci: 3008 38256726-38263664 ~-7K 15917(AOC3)(+)Loci: 4292 38420147-38427921 ~-8K 15927(VAT1)(-)Loci: 4293 38449839-38530657 ~-81K 15931(BRCA1)(-)Loci: 4287 37530523-37560548 ~-30K 15871(RAB5C)(-)Link out to UCSC