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0AMOL2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionAngiomotin-like protein 2 (leman coiled-coil protein) (lccp).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains assigned to SynO:
Soluble N-ethylmaleimide attachment protein receptor (SNARE) proteins are a family of membrane-associated proteins characterised by an alpha-helical coiled-coil domain called the SNARE motif . These proteins are classified as v-SNAREs and t-SNAREs based on their localisation on vesicle or target membrane; another classification scheme defines R-SNAREs and Q-SNAREs.s based on the conserved arginine or glutamine residue in the centre of the SNARE motif. SNAREs are localised to distinct membrane compartments of the secretory and endocytic trafficking pathways.nd contribute to the specificity of intracellular membrane fusion processes.The t-SNARE domain consists of a 4-helical bundle with a coiled-coil twist. The SNARE motif contributes to the fusion of two membranes. SNARE motifs fall into four classes: homologues of syntaxin 1a (t-SNARE).AMP-2 (v-SNARE).nd the N- and C-terminal SNARE motifs of SNAP-25. It is thought that one member from each class interacts to form a SNARE complex.The SNARE motif represented in this entry is found in the N-terminal domains of certain syntaxin family members: syntaxin 1a.hich is required for neurotransmitter release.yntaxin 6.hich is found in endosomal transport vesicles .east Sso1p .nd Vam3p. yeast syntaxin essential for vacuolar fusion . The SNARE motifs in these proteins share structural similarity.espite having a low level of sequence similarity.
InterPro domains unassigned to SynO:
Angiogenesis.he process whereby new blood vessels are formed by amechanism of sprouting from existing recently been the subjectof intense research. Angiostatin. proteolytically generated fragment ofplasminogen consisting of the first four kringle domains.s a potentangiogenesis inhibitor. Whilst this protein has been known for some time.ntil recently its mechanism of action was unknown. A functional angiostatin-binding protein has been described that inhibits endothelial cell motilityand proliferation.ey stages in angiogenesis . This protein has beennamed angiomotin.Angiomotin was identified via a yeast two-hybrid screen for proteins thatinteract with angiostatin. It is a 72kDa cell-surface associated proteinexpressed in endothelium and other tissues where angiogenesis occurs.uchas placenta and tumours. It appears that angiomotin stimulates angiogenesisby increasing cell motility and that binding of angiostatin inhibits thisprocess . Two paralogues of angiomotin have recently been cloned andtheir amino acid sequences determined. Together with angiomotin.heseproteins form a novel family bearing little sequence similarity to otherknown proteins. Sequence analysis has revealed putative coiled-coil and PDZ-binding domains .
SequencesProtein: AMOL2_HUMAN (779 aa)
mRNA: AK223598 NM_016201
Local Annotation
Synapse Ontology
Fusion of intracellular membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
sdb:0049 synaptic vesicle fusion  (Evidence:domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:domains)
sdb:0328 transmitters release and endocytosis  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 806 residues, 135556879-135559295Exon2: 62 residues, 135560071-135560251Exon3: 75 residues, 135560814-135561035Exon4: 104 residues, 135561637-135561945Exon5: 100 residues, 135563043-135563339Exon6: 33 residues, 135567348-135567441Exon7: 50 residues, 135567814-135567959Exon8: 104 residues, 135569028-135569335Exon9: 267 residues, 135572231-135573026Exon10: 76 residues, 135575873-135576096Exon11: 2 residues, -Jump to AMOL2_HUMANExon1: 72 residues, 135559082-135559295Exon2: 61 residues, 135560071-135560248Exon3: 75 residues, 135560814-135561035Exon4: 102 residues, 135561637-135561939Exon5: 100 residues, 135563043-135563339Exon6: 33 residues, 135567348-135567441Exon7: 50 residues, 135567814-135567959Exon8: 104 residues, 135569028-135569335Exon9: 267 residues, 135572231-135573026Exon10: 36 residues, 135575873-135575977Exon11: 2 residues, -Jump to AMOL2_HUMAN  
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