SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0AMACR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAMACR
DescriptionAlpha-methylacyl-coa racemase (ec 5.1.99.4) (2-methylacyl-coa racemase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0005777 peroxisome (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/769092483.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This is a family of enzymes with diverse function.ncluding fatty-acid CoA racemase enzymes such as arylpropionyl-CoA epimerase a key enzyme in the inversion metabolism of ibuprofen.arnitine dehydratase (CAIB) () and bile acid-inducible operon protein F (BAIF) .The 2-arylpropionic acid derivatives.ncluding ibuprofen.re the most widely used anti-inflammatory analgesic cyclooxygenase inhibitors. The (-)-R-enantiomer.hich is inactive in terms of cyclooxygenase inhibition.s epimerized in vivo via 2-arylpropionyl-coenzyme A (CoA) epimerase to the cyclooxygenase-inhibiting (+)-S-enantiomer. In addition to its obvious importance in drug metabolism.he homology of the epimerase with carnitine dehydratases from several species suggests that this protein.hich up to now has only been characterized as having a role in drug transformation.as a function in lipid metabolism .Carnitine dehydratase catalyzes the dehydration of L-(-)-carnitine to crotonobetaine .
  IPR003673:L-carnitine dehydratase/bile acid-inducible protein F
IPR003673:CoA_transf_3 
Evalue:-95.2839965820313 
Location:53-244IPR002086:ALDEHYDE_DEHYDR_GLU 
Evalue:0 
Location:9-16
SequencesProtein: AMACR_HUMAN (382 aa)
mRNA: NM_014324
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01796
  Level 3 annotation:
    
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 568 residues, 34023662-34025364Exon2: 64 residues, 34034502-34034689Exon3: 55 residues, 34040435-34040596Exon4: 50 residues, 34041617-34041761Exon5: 111 residues, 34043634-34043963Exon6: 2 residues, -Jump to AMACR_HUMAN  
Tune and view alternative isoforms