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0ALK_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionAlk tyrosine kinase receptor precursor (ec (anaplastic lymphoma kinase) (cd246 antigen).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004716 receptor signaling protein tyrosine kinase ... (TAS)
0004714 transmembrane receptor protein tyrosine kin... (IDA)
0007420 brain development (TAS)
0007399 neurogenesis (IMP)
0006487 protein amino acid N-linked glycosylation (IMP)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Protein kinases comprise a large family of enzymes that mediate the response of eukaryotic cells to external stimuli by phosphorylation of hydroxyamino acids. The enzymes fall into two broad classes.haracterised with respect to substrate specificity: serine/threonine specific and tyrosine specific . Tyrosine phosphorylating activity was originally detected in two viral transforming proteins .ut many retroviral transforming proteins and their cellular counterparts have since been shown to possess such activity. The growth factor receptors.hich are activated by ligand binding.nd theinsulin-related peptide also family members.
  IPR001245:Tyrosine protein kinase
A 170 amino acid domain.he so-called MAM been recognised in the extracellular region of functionally diverse proteins . These proteins have a modular.eceptor-like architecture comprising a signal peptide.n N-terminal extracellular domain. single transmembrane domain and an intracellular domain. Such proteins include meprin (a cell surface glycoprotein) ; A5 antigen (a developmentally-regulated cell surface protein) ; and receptor-like tyrosine protein phosphatase . The MAM domain is thought to have an adhesive function. It contains 4 conserved cysteine residues.hich probably form disulphide bridges.
Low density lipoprotein (LDL) is the major cholesterol-carrying lipoprotein of plasma. The receptor protein binds LDL and transports it into cells by endocytosis. In order to be internalised.he receptor-ligand complex must first cluster into clathrin-coated pits. Seven successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein .The LDL-receptor class A domain contains 6 disulphide-bound cysteines and a highly conserved cluster of negatively charged amino acids.f which many are clustered on one face of the module . A schematic representation of this domain is shown here:In LDL-receptors the class A domains form the binding site for LDL and calcium . The acidic residues between the fourth and sixth cysteines are important for high-affinity binding of positively charged sequences in LDLRs ligands . The repeat has been shown to consist of a beta-hairpin structure followed by a series of beta turns. In the absence of calcium.DL-A domains are unstructured; the bound calcium ion imparts structural integrity.Following these repeats is a 350 residue domain that resembles part of the epidermal growth factor (EGF) precursor .Similar domains have been found (see references in ) in several extracellular and membrane proteins (see examples).Numerous familial hypercholestorolemia mutations of the LDL receptor alter the calcium coordinating residue of LDL-A domains or other crucial scaffolding residues.
  IPR002172:Low density lipoprotein-receptor, class A
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
SequencesProtein: ALK_HUMAN (1620 aa)
mRNA: NM_004304
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords)
KO assignmentK05119
  Level 3 annotation:
    anaplastic lymphoma kinase
  Level 2 annotation:
    Cytokine receptors
    CD molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 383 residues, 29269145-29270292Exon2: 32 residues, 29273139-29273230Exon3: 47 residues, 29273911-29274046Exon4: 36 residues, 29283540-29283642Exon5: 33 residues, 29286155-29286248Exon6: 34 residues, 29290353-29290451Exon7: 45 residues, 29297075-29297205Exon8: 23 residues, 29298713-29298778Exon9: 32 residues, 29298886-29298977Exon10: 64 residues, 29299711-29299898Exon11: 37 residues, 29301830-29301935Exon12: 53 residues, 29303291-29303444Exon13: 35 residues, 29303943-29304042Exon14: 63 residues, 29305253-29305436Exon15: 50 residues, 29308673-29308818Exon16: 46 residues, 29309934-29310066Exon17: 52 residues, 29316049-29316200Exon18: 56 residues, 29327474-29327637Exon19: 45 residues, 29351468-29351597Exon20: 33 residues, 29351771-29351866Exon21: 58 residues, 29373257-29373427Exon22: 35 residues, 29394673-29394774Exon23: 46 residues, 29397120-29397252Exon24: 46 residues, 29404719-29404851Exon25: 44 residues, 29460101-29460229Exon26: 69 residues, 29608284-29608486Exon27: 57 residues, 29771219-29771384Exon28: 42 residues, 29793947-29794067Exon29: 526 residues, 29996362-29997936Exon30: 2 residues, -Jump to ALK_HUMAN