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0ALDOA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameALDOA
DescriptionFructose-bisphosphate aldolase a (ec 4.1.2.13) (muscle-type aldolase) (lung cancer antigen ny-lu-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004332 fructose-bisphosphate aldolase activity (TAS)
0006000 fructose metabolism (TAS)
0006096 glycolysis (TAS)
0006941 striated muscle contraction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Fructose-bisphosphate aldolase () .s a glycolytic enzyme that catalyses the reversible aldol cleavage or condensation of fructose-1.-bisphosphate into dihydroxyacetone-phosphate and glyceraldehyde 3-phosphate. There are two classes of fructose-bisphosphate aldolases with different catalytic mechanisms: class I enzymes are found in animals.o not require a metal ion.nd are characterised by the formation of a Schiff base intermediate between a highly conserved active site lysine and a substrate carbonyl group.hile the class II enzymes are produced in bacteria and fungi.nd require an active-site divalent metal ion. This entry represents the class I enzymes.In vertebrates.hree forms of this enzyme are found: aldolase A is expressed in muscle.ldolase B in liver.idney.tomach and intestine.nd aldolase C in brain.eart and ovary. The different isozymes have different catalytic functions: aldolases A and C are mainly involved in glycolysis.hile aldolase B is involved in both glycolysis and gluconeogenesis. Defects in aldolase B result in hereditary fructose intolerance.
  IPR000741:Fructose-bisphosphate aldolase, class-I
This entry represents the TIM beta/alpha barrel found in aldolase and in related proteins. This TIM barrel usually covers the entire protein structure. Proteins containing this TIM barrel domain include class I aldolases.lass I DAHP synthases.lass II fructose-bisphosphate aldolases (FBP aldolases).nd 5-aminolaevulinate dehydratase (a hybrid of classes I and II aldolases) .
  IPR013785:Aldolase-type TIM barrel
IPR000741:Glycolytic 
Evalue:-272.142669677734 
Location:14-363
SequencesProtein: ALDOA_HUMAN (363 aa)
mRNA: NM_000034
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentK01623
  Level 3 annotation:
    fructose-bisphosphate aldolase, class I
  Level 2 annotation:
    Glycolysis / Gluconeogenesis
    Pentose phosphate pathway
    Fructose and mannose metabolism
    Carbon fixation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 17 residues, 29971991-29972039Exon2: 14 residues, 29972285-29972321Exon3: 50 residues, 29973605-29973749Exon4: 54 residues, 29973993-29974149Exon5: 175 residues, 29982550-29983070Exon6: 29 residues, 29983245-29983327Exon7: 46 residues, 29986055-29986188Exon8: 72 residues, 29986271-29986483Exon9: 20 residues, 29987467-29987522Exon10: 55 residues, 29987639-29987800Exon11: 30 residues, 29988127-29988211Exon12: 60 residues, 29988320-29988495Exon13: 68 residues, 29988651-29988851Exon14: 101 residues, 29988938-29989235Exon15: 2 residues, -Jump to ALDOA_HUMAN  
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Loci Cluster (Details)Loci: 2933 29709562-29724205 ~-15K 13857(KIF22)(+)Loci: 4218 29924337-29929902 ~-6K 13883(DOC2A)(-)Loci: 2934 29971991-29989235 ~-17K 13889(ALDOA)(+)Loci: 2935 30102426-30107897 ~-5K 13900(CORO1A)(+)Loci: 2936 30113969-30123150 ~-9K 13906(SULT1A3)(+)Loci: 2932 29374627-29383801 ~-9K 13851(SULT1A3)(+)Link out to UCSC