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0ALDH2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameALDH2
DescriptionAldehyde dehydrogenase, mitochondrial precursor (ec 1.2.1.3) (aldh class 2) (aldhi) (aldh-e2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004029 aldehyde dehydrogenase (NAD) activity (TAS)
0004030 aldehyde dehydrogenase [NAD(P)+] activity (TAS)
0005489 electron transporter activity (TAS)
0006066 alcohol metabolism (TAS)
0005975 carbohydrate metabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Aldehyde dehydrogenases ( and ) are enzymes which oxidizea wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least fourdifferent forms of the enzyme are known : class-1 (or Ald C) a tetramericcytosolic enzyme.lass-2 (or Ald M) a tetrameric mitochondrial enzyme.lass-3 (or Ald D) a dimeric cytosolic enzyme.nd class IV a microsomal enzyme.Aldehyde dehydrogenases have also been sequenced from fungal and bacterialspecies. A number of enzymes are known to be evolutionary related to aldehydedehydrogenases.A glutamic acid and a cysteine residue have been implicated in the catalyticactivity of mammalian aldehyde dehydrogenase. These residues are conserved inall the enzymes of this family.Some of the proteins in this family are allergens. Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen.tings.rugs.r food) that.n most people.esult in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans [WHO/IUIS Allergen Nomenclature Subcommittee King T.P..offmann D..oewenstein H..arsh D.G..latts-Mills T.A.E..homas W. Bull. World Health Organ. 72:797-806(1994)]. This nomenclature system is defined by a designation that is composed ofthe first three letters of the genus; a space; the first letter of thespecies name; a space and an arabic number. In the event that two speciesnames have identical designations.hey are discriminated from one anotherby adding one or more letters (as necessary) to each species designation. The allergens in this family include allergens with the following designations: Alt a 10 and Cla h 3.
  IPR002086:Aldehyde dehydrogenase
Aldehyde dehydrogenases ( and ) are enzymes which oxidizea wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least fourdifferent forms of the enzyme are known : class-1 (or Ald C) a tetramericcytosolic enzyme.lass-2 (or Ald M) a tetrameric mitochondrial enzyme.lass-3 (or Ald D) a dimeric cytosolic enzyme.nd class IV a microsomal enzyme.Aldehyde dehydrogenases have also been sequenced from fungal and bacterialspecies. A number of enzymes are known to be evolutionary related to aldehydedehydrogenases.A glutamic acid and a cysteine residue have been implicated in the catalyticactivity of mammalian aldehyde dehydrogenase. These residues are conserved inall the enzymes of this family.
  IPR012303:NAD-dependent aldehyde dehydrogenase
IPR002086:Aldedh 
Evalue:-262.366546630859 
Location:45-508IPR001484:PYROKININ 
Evalue:0 
Location:8-13
SequencesProtein: ALDH2_HUMAN (517 aa)
mRNA: NM_000690
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00128
  Level 3 annotation:
    aldehyde dehydrogenase (NAD+)
  Level 2 annotation:
    Glycolysis / Gluconeogenesis
    Ascorbate and aldarate metabolism
    Pyruvate metabolism
    Propanoate metabolism
    Butanoate metabolism
    Fatty acid metabolism
    Bile acid biosynthesis
    Glycerolipid metabolism
    Valine
     leucine and isoleucine degradation
    Lysine degradation
    Arginine and proline metabolism
    Histidine metabolism
    Tryptophan metabolism
    beta-Alanine metabolism
    Limonene and pinene degradation
    1
    2-Dichloroethane degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 186 residues, 110688728-110689283Exon2: 37 residues, 110704104-110704209Exon3: 49 residues, 110705344-110705485Exon4: 28 residues, 110707453-110707533Exon5: 39 residues, 110712009-110712121Exon6: 45 residues, 110712620-110712749Exon7: 40 residues, 110713492-110713606Exon8: 36 residues, 110714247-110714350Exon9: 63 residues, 110714784-110714969Exon10: 57 residues, 110720264-110720429Exon11: 54 residues, 110722092-110722250Exon12: 40 residues, 110726045-110726160Exon13: 147 residues, 110731729-110732165Exon14: 2 residues, -Jump to ALDH2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4075 110566278-110608122 ~-42K 9715(BRAP)(-)Loci: 2788 110688728-110732165 ~-43K 9721(ALDH2)(+)Loci: 4074 110374401-110521863 ~-147K 9714(ATXN2)(-)Link out to UCSC