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0AL4A1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameALDH4A1
DescriptionDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor (ec 1.5.1.12) (p5c dehydrogenase) (aldehyde dehydrogenase 4a1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005759 mitochondrial matrix (TAS)
0003842 1-pyrroline-5-carboxylate dehydrogenase act... (TAS)
0004029 aldehyde dehydrogenase (NAD) activity (TAS)
0005489 electron transporter activity (TAS)
0006562 proline catabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Aldehyde dehydrogenases ( and ) are enzymes which oxidizea wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least fourdifferent forms of the enzyme are known : class-1 (or Ald C) a tetramericcytosolic enzyme.lass-2 (or Ald M) a tetrameric mitochondrial enzyme.lass-3 (or Ald D) a dimeric cytosolic enzyme.nd class IV a microsomal enzyme.Aldehyde dehydrogenases have also been sequenced from fungal and bacterialspecies. A number of enzymes are known to be evolutionary related to aldehydedehydrogenases.A glutamic acid and a cysteine residue have been implicated in the catalyticactivity of mammalian aldehyde dehydrogenase. These residues are conserved inall the enzymes of this family.Some of the proteins in this family are allergens. Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen.tings.rugs.r food) that.n most people.esult in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans [WHO/IUIS Allergen Nomenclature Subcommittee King T.P..offmann D..oewenstein H..arsh D.G..latts-Mills T.A.E..homas W. Bull. World Health Organ. 72:797-806(1994)]. This nomenclature system is defined by a designation that is composed ofthe first three letters of the genus; a space; the first letter of thespecies name; a space and an arabic number. In the event that two speciesnames have identical designations.hey are discriminated from one anotherby adding one or more letters (as necessary) to each species designation. The allergens in this family include allergens with the following designations: Alt a 10 and Cla h 3.
  IPR002086:Aldehyde dehydrogenase
The delta(1)-pyrroline-5-carboxylate synthetase () a mitochondrial inner membrane.TP- and NADPH-dependent.ifunctional enzyme.atalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate. critical step in the de novo biosynthesis of proline and ornithine. It is the rate-limiting enzyme in proline biosynthesis and is subject to feedback inhibition by proline. 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH This model represents one of several related branches of delta-1-pyrroline-5-carboxylate dehydrogenase.
  IPR005931:delta-1-pyrroline-5-carboxylate dehydrogenase 1
Aldehyde dehydrogenases ( and ) are enzymes which oxidizea wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least fourdifferent forms of the enzyme are known : class-1 (or Ald C) a tetramericcytosolic enzyme.lass-2 (or Ald M) a tetrameric mitochondrial enzyme.lass-3 (or Ald D) a dimeric cytosolic enzyme.nd class IV a microsomal enzyme.Aldehyde dehydrogenases have also been sequenced from fungal and bacterialspecies. A number of enzymes are known to be evolutionary related to aldehydedehydrogenases.A glutamic acid and a cysteine residue have been implicated in the catalyticactivity of mammalian aldehyde dehydrogenase. These residues are conserved inall the enzymes of this family.
  IPR012303:NAD-dependent aldehyde dehydrogenase
IPR002086:Aldedh 
Evalue:-117.397941589355 
Location:74-547
SequencesProtein: AL4A1_HUMAN (563 aa)
mRNA: NM_003748
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00294
  Level 3 annotation:
    1-pyrroline-5-carboxylate dehydrogenase
  Level 2 annotation:
    Glutamate metabolism
    Arginine and proline metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 509 residues, 19070512-19072038Exon2: 41 residues, 19073543-19073662Exon3: 42 residues, 19074462-19074584Exon4: 53 residues, 19075395-19075548Exon5: 18 residues, 19076288-19076336Exon6: 67 residues, 19076496-19076693Exon7: 26 residues, 19078380-19078454Exon8: 64 residues, 19080780-19080968Exon9: 27 residues, 19082204-19082279Exon10: 52 residues, 19082359-19082509Exon11: 54 residues, 19084553-19084709Exon12: 18 residues, 19085544-19085592Exon13: 33 residues, 19088442-19088535Exon14: 33 residues, 19089092-19089186Exon15: 41 residues, 19101542-19101659Exon16: 2 residues, -Jump to AL4A1_HUMAN  
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