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0AL3A2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameALDH3A2
DescriptionFatty aldehyde dehydrogenase (ec 1.2.1.3) (aldehyde dehydrogenase, microsomal) (aldehyde dehydrogenase family 3 member a2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004028 aldehyde dehydrogenase activity (TAS)
0007417 central nervous system development (TAS)
0008544 epidermis development (TAS)
0006629 lipid metabolism (TAS)
0007422 peripheral nervous system development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Aldehyde dehydrogenases ( and ) are enzymes which oxidizea wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least fourdifferent forms of the enzyme are known : class-1 (or Ald C) a tetramericcytosolic enzyme.lass-2 (or Ald M) a tetrameric mitochondrial enzyme.lass-3 (or Ald D) a dimeric cytosolic enzyme.nd class IV a microsomal enzyme.Aldehyde dehydrogenases have also been sequenced from fungal and bacterialspecies. A number of enzymes are known to be evolutionary related to aldehydedehydrogenases.A glutamic acid and a cysteine residue have been implicated in the catalyticactivity of mammalian aldehyde dehydrogenase. These residues are conserved inall the enzymes of this family.Some of the proteins in this family are allergens. Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen.tings.rugs.r food) that.n most people.esult in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans [WHO/IUIS Allergen Nomenclature Subcommittee King T.P..offmann D..oewenstein H..arsh D.G..latts-Mills T.A.E..homas W. Bull. World Health Organ. 72:797-806(1994)]. This nomenclature system is defined by a designation that is composed ofthe first three letters of the genus; a space; the first letter of thespecies name; a space and an arabic number. In the event that two speciesnames have identical designations.hey are discriminated from one anotherby adding one or more letters (as necessary) to each species designation. The allergens in this family include allergens with the following designations: Alt a 10 and Cla h 3.
  IPR002086:Aldehyde dehydrogenase
Aldehydes are produced as intermediates during the metabolism of many different compounds including amino acids.arbohydrates.ipids vitamins and steroids . They are highly reactive compounds whose buildup to excess levels can cause cytotoxic.enotoxic and carcinogenic effects. Aldehyde dehydrogenases oxidise these compounds to their respective carboxylic acids. This is necessary both for the operation of these metabolic pathways.nd to prevent the concentration of aldehydes within the cell from reaching toxic levels.Proteins in this entry are NAD(P)-dependent aldehyde dehydrogenases.ound in a variety of organisms.ncluding general aldehyde dehydrogensases ().atty aldehyde dehydrogenases ().nd coniferyl aldehyde dehydrogenase (). Structural studies of the Rattus norvegicus protein () show that this enzyme is a homodimer where each subunit consists of two alpha-beta-alpha domains . The mode of NAD binding differs substantially from that commonly associated with the Rossman fold.
  IPR012394:Aldehyde dehydrogenase NAD(P)-dependent
IPR002086:Aldedh 
Evalue:-47.9586067199707 
Location:3-425
SequencesProtein: AL3A2_HUMAN (485 aa)
mRNA: NM_000382 NM_001031806
Local Annotation
Synapse Ontology
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentK00128
  Level 3 annotation:
    aldehyde dehydrogenase (NAD+)
  Level 2 annotation:
    Glycolysis / Gluconeogenesis
    Ascorbate and aldarate metabolism
    Pyruvate metabolism
    Propanoate metabolism
    Butanoate metabolism
    Fatty acid metabolism
    Bile acid biosynthesis
    Glycerolipid metabolism
    Valine
     leucine and isoleucine degradation
    Lysine degradation
    Arginine and proline metabolism
    Histidine metabolism
    Tryptophan metabolism
    beta-Alanine metabolism
    Limonene and pinene degradation
    1
    2-Dichloroethane degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 125 residues, 19492655-19493029Exon2: 79 residues, 19495451-19495683Exon3: 30 residues, 19496451-19496537Exon4: 71 residues, 19500270-19500479Exon5: 41 residues, 19501649-19501767Exon6: 49 residues, 19505031-19505173Exon7: 57 residues, 19507237-19507404Exon8: 35 residues, 19508852-19508952Exon9: 80 residues, 19515625-19515861Exon10: 43 residues, 19517055-19517180Exon11: 679 residues, 19519462-19521495Exon12: 2 residues, -Jump to AL3A2_HUMANExon1: 125 residues, 19492655-19493029Exon2: 79 residues, 19495451-19495683Exon3: 30 residues, 19496451-19496537Exon4: 71 residues, 19500270-19500479Exon5: 41 residues, 19501649-19501767Exon6: 49 residues, 19505031-19505173Exon7: 57 residues, 19507237-19507404Exon8: 35 residues, 19508852-19508952Exon9: 80 residues, 19515625-19515861Exon10: 681 residues, 19519462-19521500Exon11: 2 residues, -Jump to AL3A2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2989 19221658-19227449 ~-6K 15306(MAPK7)(+)Loci: 2990 19492655-19521500 ~-29K 15314(ALDH3A2)(+)Loci: 4273 19749343-19821721 ~-72K 15324(AKAP10)(-)Loci: 2988 19081302-19180620 ~-99K 15297(EPN2)(+)Link out to UCSC