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0AKAP5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAKAP5
DescriptionA-kinase anchor protein 5 (a-kinase anchor protein 79 kda) (akap 79) (camp-dependent protein kinase regulatory subunit ii high affinity binding protein) (h21).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005886 plasma membrane (NAS)
0051018 protein kinase A binding (TAS)
0007165 signal transduction (NAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Cell signalling mediated via GPCRs (G-protein-coupled receptors) involves the assembly of receptors.-proteins.ffectors and downstream elements into complexes that approach in design solid-state signalling devices. Scaffold molecules.uch as the AKAPs (A-kinase anchoring proteins).ere discovered more than a decade ago and represent dynamic platforms.nabling multivalent signalling . This family of functionally related proteins is classified on the basis of their ability to associate with the PKA holoenzyme inside cells. A shared property of most.f not all.KAPs is the ability to form multivalent signal transduction complexes. Each anchoring protein contains at least two functional motifs . The conserved PKA binding motif forms an amphipathic helix of 14-18 residues that interacts with hydrophobic determinants located in the extreme N-terminus of the regulatory subunit dimmer. The subcellular address of each AKAP is encoded by a unique targeting motif. Gravin.n autoantigen recognised by serum from myasthenia gravis patients contains 3 repeats of this domain .
  IPR001573:Protein kinase A anchoring region
IPR001573:PkinA_anch 
Evalue:-12.3872165679932 
Location:73-103
SequencesProtein: AKAP5_HUMAN (427 aa)
mRNA: NM_004857
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
?
sdb:0334 inhibitory postsynapstic component  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 866 residues, 64003577-64006172Exon2: 2 residues, -Jump to AKAP5_HUMAN  
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Loci Cluster (Details)Loci: 2847 64003577-64006172 ~-3K 11293(AKAP5)(+)Loci: 2846 63924845-63996474 ~-72K 11292(MTHFD1)(+)Link out to UCSC