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0AKA11_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAKAP11
DescriptionA-kinase anchor protein 11 (protein kinase a anchoring protein 11) (prka11) (a kinase anchor protein 220 kda) (akap 220) (hakap220).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0051018 protein kinase A binding (TAS)
0008157 protein phosphatase 1 binding (TAS)
0007243 protein kinase cascade (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides.esigned to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs).re potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction .
  IPR008382:A-kinase anchor 110 kDa
IPR008382:AKAP_110 
Evalue:-3.56863617897034 
Location:1825-1901IPR008382:AKAP_110 
Evalue:0 
Location:350-1675
SequencesProtein: AKA11_HUMAN (1901 aa)
mRNA: NM_016248
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 26 residues, 41744288-41744364Exon2: 18 residues, 41758121-41758171Exon3: 35 residues, 41758435-41758535Exon4: 41 residues, 41764520-41764637Exon5: 18 residues, 41767830-41767878Exon6: 47 residues, 41769183-41769318Exon7: 90 residues, 41770668-41770933Exon8: 1502 residues, 41771498-41775999Exon9: 54 residues, 41780589-41780745Exon10: 30 residues, 41785182-41785266Exon11: 17 residues, 41786029-41786076Exon12: 55 residues, 41789663-41789824Exon13: 1395 residues, 41791223-41795402Exon14: 2 residues, -Jump to AKA11_HUMAN  
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