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0AKA10_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAKAP10
DescriptionA kinase anchor protein 10, mitochondrial precursor (protein kinase a anchoring protein 10) (prka10) (dual specificity a-kinase anchoring protein 2) (d-akap-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (TAS)
0008104 protein localization (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
RGS (Regulator of G Protein Signalling) proteins are multi-functional.TPase-accelerating proteins that promote GTP hydrolysis by the alpha subunit of heterotrimeric G proteins.hereby inactivating the G protein and rapidly switching off G protein-coupled receptor signalling pathways . Upon activation by GPCRs.eterotrimeric G proteins exchange GDP for GTP.re released from the receptor.nd dissociate into free.ctive GTP-bound alpha subunit and beta-gamma dimer.oth of which activate downstream effectors. The response is terminated upon GTP hydrolysis by the alpha subunit ().hich can then bind the beta-gamma dimer (. and the receptor. RGS proteins markedly reduce the lifespan of GTP-bound alpha subunits by stabilising the G protein transition state.All RGS proteins contain an RGS-box (or RGS domain).hich is required for activity. Some small RGS proteins such as RGS1 and RGS4 are comprised of little more than an RGS domain.hile others also contain additional domains that confer further functionality . RGS domains can be found in conjunction with a variety of domains.ncluding: DEP for membrane targeting ().DZ for binding to GPCRs ().TB for phosphotyrosine-binding ().BD for Ras-binding ().oLoco for guanine nucleotide inhibitor activity ().X for phosphatidylinositol-binding ().XA that is associated with PX ().H for stimulating guanine nucleotide exchange ().nd GGL (G protein gamma subunit-like) for binding G protein beta subunits () . Those RGS proteins that contain GGL domains can interact with G protein beta subunits to form novel dimers that prevent G protein gamma subunit binding and G protein alpha subunit association.hereby preventing heterotrimer formation.
  IPR000342:Regulator of G protein signalling
IPR000342:RGS 
Evalue:-29.0132282657338 
Location:379-505IPR000342:RGS 
Evalue:-27.8860566476932 
Location:125-369
SequencesProtein: AKA10_HUMAN (662 aa)
mRNA: NM_007202
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 265 residues, 19749343-19750137Exon2: 34 residues, 19753085-19753181Exon3: 19 residues, 19753830-19753883Exon4: 29 residues, 19763940-19764023Exon5: 38 residues, 19768312-19768422Exon6: 60 residues, 19775709-19775883Exon7: 50 residues, 19780190-19780335Exon8: 47 residues, 19783617-19783754Exon9: 43 residues, 19784791-19784915Exon10: 30 residues, 19785730-19785815Exon11: 35 residues, 19791311-19791410Exon12: 188 residues, 19801918-19802476Exon13: 63 residues, 19806744-19806927Exon14: 18 residues, 19812318-19812366Exon15: 77 residues, 19821496-19821721Exon16: 2 residues, -Jump to AKA10_HUMAN  
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Loci Cluster (Details)Loci: 2989 19221658-19227449 ~-6K 15306(MAPK7)(+)Loci: 2990 19492655-19521500 ~-29K 15314(ALDH3A2)(+)Loci: 4273 19749343-19821721 ~-72K 15324(AKAP10)(-)Loci: 2988 19081302-19180620 ~-99K 15297(EPN2)(+)Link out to UCSC