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0AK1C3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAKR1C3
DescriptionAldo-keto reductase family 1 member c3 (ec 1.-.-.-) (trans-1,2- dihydrobenzene-1,2-diol dehydrogenase) (ec 1.3.1.20) (3-alpha- hydroxysteroid dehydrogenase type 2) (ec 1.1.1.213) (3-alpha-hsd type 2) (3-alpha-hsd type ii, brain) (prostaglandin f synthase) (ec 1.1.1.188) (pgfs) (estradiol 17-beta-dehydrogenase) (ec 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-hsd 5) (chlordecone reductase homolog hakrb) (ha1753) (dihydrodiol dehydrogenase type i) (dihydrodiol dehydrogenase 3) (dd3) (dd-3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004033 aldo-keto reductase activity (TAS)
0005489 electron transporter activity (TAS)
0008283 cell proliferation (TAS)
0006629 lipid metabolism (TAS)
0006693 prostaglandin metabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The aldo-keto reductase family includes a number of related monomeric NADPH-dependent oxidoreductases.uch as aldehyde reductase.ldose reductase.rostaglandin F synthase.ylose reductase.ho crystallin.nd many others . All possess a similar structure.ith a beta-alpha-beta fold characteristic of nucleotide binding proteins . The fold comprises a parallel beta-8/alpha-8-barrel.hich contains a novel NADP-binding motif. The binding site is located in a large.eep.lliptical pocket in the C-terminal end of the beta sheet.he substrate being bound in an extended conformation. The hydrophobic nature of the pocket favours aromatic and apolar substrates over highly polar ones . Binding of the NADPH coenzyme causes a massive conformational change.eorienting a loop.ffectively locking the coenzyme in place. This binding is more similar to FAD- than to NAD(P)-binding oxidoreductases . Some proteins of this entry contain a K+ ion channel beta chain regulatory domain; these are reported to have oxidoreductase activity .
  IPR001395:Aldo/keto reductase
IPR001395:Aldo_ket_red 
Evalue:-156.494842529297 
Location:10-301
SequencesProtein: AK1C3_HUMAN (323 aa)
mRNA: NM_003739
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentK00089
  Level 3 annotation:
    3alpha-hydroxysteroid dehydrogenase (A-specific)
  Level 2 annotation:
    Other enzymes
K00212
  Level 3 annotation:
    trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
  Level 2 annotation:
    Metabolism of xenobiotics by cytochrome P450
K04119
  Level 3 annotation:
    prostaglandin-F synthase
  Level 2 annotation:
    Arachidonic acid metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 52 residues, 5126567-5126720Exon2: 58 residues, 5128601-5128769Exon3: 41 residues, 5129625-5129742Exon4: 28 residues, 5130993-5131071Exon5: 43 residues, 5131518-5131641Exon6: 38 residues, 5134292-5134402Exon7: 57 residues, 5134676-5134842Exon8: 29 residues, 5137786-5137869Exon9: 76 residues, 5139652-5139876Exon10: 2 residues, -Jump to AK1C3_HUMAN  
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