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0ADX_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameFDX1
DescriptionAdrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0009055 electron carrier activity (TAS)
0005506 iron ion binding (TAS)
0006091 generation of precursor metabolites and energy (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The ferredoxin protein family are electron carrier proteins with an iron-sulphur cofactor that act in a wide variety of metabolic reactions. Ferredoxins can be divided into several subgroups depending upon the physiological nature of the iron-sulphur cluster(s) and according to sequence similarities. This entry represents members of the 2Fe-2S ferredoxin family that have a general core structure consisting of beta(2)-alpha-beta(2).hich includes putidaredoxin and terpredoxin.nd adrenodoxin . This entry also represents 2Fe-2S ferredoxin domains from multidomain proteins.uch as aldehyde oxidoreductase (N-terminal).anthine oxidase (N-terminal).hthalate dioxygenase reductase (C-terminal).uccinate dehydrogenase iron-sulphur protein (N-terminal).nd methane monooxygenase reductase (N-terminal). In addition.his entry includes the N-terminal additional domain of threonyl-tRNA synthetase (ThrRS). class II multi-domain enzyme that represses its own translation; the N-terminal additional domain has a beta(2)-alpha-beta(2) core structure .
  IPR012675:2Fe-2S Ferredoxin-like fold
The ferredoxin protein family are electron carrier proteins with an iron-sulphur cofactor that act in a wide variety of metabolic reactions. Ferredoxins can be divided into several subgroups depending upon the physiological nature of the iron-sulphur cluster(s) and according to sequence similarities. This entry represents members of the 2Fe-2S ferredoxin family that have a general core structure consisting of beta(2)-alpha-beta(2).hich includes putidaredoxin and terpredoxin.nd adrenodoxin . They are proteins of around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This conserved region is also found as a domain in various metabolic enzymes and in multidomain proteins.uch as aldehyde oxidoreductase (N-terminal).anthine oxidase (N-terminal).hthalate dioxygenase reductase (C-terminal).uccinate dehydrogenase iron-sulphur protein (N-terminal).nd methane monooxygenase reductase (N-terminal).
  IPR001041:Ferredoxin
Adrenodoxin.utidaredoxin and terpredoxin are soluble 2Fe-2S iron-sulphurproteins that act as single electron carriers. They are a subgroup of the ferredoxinfamily of iron-sulphur proteins.In mitochondrial monooxygenase systems.drenodoxin transfers an electron fromNADPH:adrenodoxin reductase to membrane-bound P450 . In bacteria.utidaredoxinand terpredoxin serve as electron carriers between corresponding NADH-dependent ferredoxinreductases and soluble P450 . The exact functions of other membersof this family are not known.
  IPR001055:Adrenodoxin
IPR012675:Ferredoxin_fold 
Evalue:-32.5528411865234 
Location:64-168
SequencesProtein: ADX_HUMAN (184 aa)
mRNA: NM_004109
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 146 residues, 109805803-109806239Exon2: 43 residues, 109811767-109811892Exon3: 45 residues, 109832851-109832981Exon4: 844 residues, 109838287-109840814Exon5: 2 residues, -Jump to ADX_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2702 109805803-109840814 ~-35K 7711(FDX1)(+)Loci: 3989 109605375-109672647 ~-67K 7709(RDX)(-)Link out to UCSC