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0ADRB2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameADRB2
DescriptionBeta-2 adrenergic receptor (beta-2 adrenoceptor) (beta-2 adrenoreceptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005768 endosome (TAS)
0005887 integral to plasma membrane (TAS)
0005764 lysosome (TAS)
0005886 plasma membrane (TAS)
0004941 beta2-adrenergic receptor activity (TAS)
0005515 protein binding (IPI)
0000187 activation of MAPK activity (TAS)
0007190 adenylate cyclase activation (TAS)
0008333 endosome to lysosome transport (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)
0007188 G-protein signaling, coupled to cAMP nucleo... (TAS)
0007243 protein kinase cascade (TAS)
0006898 receptor mediated endocytosis (TAS)
0007171 transmembrane receptor protein tyrosine kin... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In the periphery.he adrenergic system plays an important role in regulating the cardiovascular system . Increased sympathetic discharge to the heart increases the rate and force of contraction mediated through beta-1 receptors. Circulating adrenaline also acts on cardiac tissue.nd.n addition.cts both on alpha-1 adrenoceptors in arterial smooth muscle.timulating vasoconstriction.nd on beta-2 adrenoceptors in vascular beds of skeletal muscle.timulating vasodilation. In the CNS.oradrenaline is thought to be involved in the regulation of mood.nd various psychoactive drugs alter noradrenergic function. Numerous drugs exert their actions via adrenoceptors: e.g..eta-2 selective agonists such as salbutamol are used in the acute treatment of asthma.hile alpha agonists prolong the action of local anaesthetics.nd act as nasal decongestants . Adrenoceptors can be divided into three main classes based on sequence similarity.eceptor pharmacology and signalling mechanisms. Further subdivisions exist within each class. A large number of agonists and antagonists distinguish between the different classes of adrenoceptor; by contrast.elatively small differences in agonist and antagonist affinities are demonstrated.specially within the alpha-1 and alpha-2 adrenoceptor subtypes .Beta-1 and beta-2 receptors often coexist.ut one subtype normallypredominates. Beta-2 receptors mediate relaxation of smooth muscle(including vascular beds.ronchus.ntestine and uterus); they mediateglycogenlysis and glucogenesis in the liver and regulate cell metabolism inskeletal muscle; they inhibit the activity of leukocytes and other bloodcells; and they are found in the heart.ut their physiological role hereis unclear. The receptors are located presynaptically in nerves.herethey facilitate neurotransmitter release.nd in the brain.here theyregulate a variety of physiological processes. Beta-2 receptors activateadenylyl cyclase through G proteins .
  IPR000332:Adrenergic receptor, beta 2
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In the periphery.he adrenergic system plays an important role in regulating the cardiovascular system . Increased sympathetic discharge to the heart increases the rate and force of contraction mediated through beta-1 receptors. Circulating adrenaline also acts on cardiac tissue.nd.n addition.cts both on alpha-1 adrenoceptors in arterial smooth muscle.timulating vasoconstriction.nd on beta-2 adrenoceptors in vascular beds of skeletal muscle.timulating vasodilation. In the CNS.oradrenaline is thought to be involved in the regulation of mood.nd various psychoactive drugs alter noradrenergic function. Numerous drugs exert their actions via adrenoceptors: e.g..eta-2 selective agonists such as salbutamol are used in the acute treatment of asthma.hile alpha agonists prolong the action of local anaesthetics.nd act as nasal decongestants . Adrenoceptors can be divided into three main classes based on sequence similarity.eceptor pharmacology and signalling mechanisms. Further subdivisions exist within each class. A large number of agonists and antagonists distinguish between the different classes of adrenoceptor; by contrast.elatively small differences in agonist and antagonist affinities are demonstrated.specially within the alpha-1 and alpha-2 adrenoceptor subtypes .
  IPR002233:Adrenergic receptor
IPR000276:7tm_1 
Evalue:-82.7212448120117 
Location:50-326IPR000332:ADRENRGCB2AR 
Evalue:0 
Location:10-30IPR000332:ADRENRGCB2AR 
Evalue:0 
Location:361-380IPR000332:ADRENRGCB2AR 
Evalue:0 
Location:387-406IPR000332:ADRENRGCB2AR 
Evalue:0 
Location:342-360IPR002233:ADRENERGICR 
Evalue:0 
Location:331-340
SequencesProtein: ADRB2_HUMAN (413 aa)
mRNA: NM_000024
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords,domains)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords,domains)
?
sdb:0219 GPCR mediated signaling  (Evidence:keywords,domains)
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK04142
  Level 3 annotation:
    adrenergic receptor, beta 2
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1150 residues, 148185000-148188447Exon2: 2 residues, -Jump to ADRB2_HUMANExon1: 671 residues, 148186368-148188379Exon2: 2 residues, -Jump to ADRB2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3499 148185000-148188447 ~-3K 29722(ADRB2)(+)Loci: 4741 148364376-148422880 ~-59K 29724(SH3TC2)(-)Loci: 3500 148705284-148714338 ~-9K 29730(GRPEL2)(+)Loci: 4742 148855037-148911200 ~-56K 29736(CSNK1A1)(-)Loci: 4740 147841291-148013909 ~-173K 29718(HTR4)(-)Link out to UCSC