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0ADA2C_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameADRA2C
DescriptionAlpha-2c adrenergic receptor (alpha-2c adrenoceptor) (alpha-2c adrenoreceptor) (subtype c4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005768 endosome (TAS)
0005887 integral to plasma membrane (TAS)
0004938 alpha2-adrenergic receptor activity (TAS)
0000187 activation of MAPK activity (TAS)
0007267 cell-cell signaling (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In the periphery.he adrenergic system plays an important role in regulating the cardiovascular system . Increased sympathetic discharge to the heart increases the rate and force of contraction mediated through beta-1 receptors. Circulating adrenaline also acts on cardiac tissue.nd.n addition.cts both on alpha-1 adrenoceptors in arterial smooth muscle.timulating vasoconstriction.nd on beta-2 adrenoceptors in vascular beds of skeletal muscle.timulating vasodilation. In the CNS.oradrenaline is thought to be involved in the regulation of mood.nd various psychoactive drugs alter noradrenergic function. Numerous drugs exert their actions via adrenoceptors: e.g..eta-2 selective agonists such as salbutamol are used in the acute treatment of asthma.hile alpha agonists prolong the action of local anaesthetics.nd act as nasal decongestants . Adrenoceptors can be divided into three main classes based on sequence similarity.eceptor pharmacology and signalling mechanisms. Further subdivisions exist within each class. A large number of agonists and antagonists distinguish between the different classes of adrenoceptor; by contrast.elatively small differences in agonist and antagonist affinities are demonstrated.specially within the alpha-1 and alpha-2 adrenoceptor subtypes .Northern analysis has demonstrated the presence of alpha-2C receptor mRNAin rat brain (including the cerebral cortex.erebellum.ippocampus andbrainstem).ut not in peripheral tissues. The receptor inhibitsadenylyl cyclase through a pertussis-toxin-insensitive G-protein belongingto the Gi/G0 class .
  IPR000735:Adrenergic receptor, alpha-2C
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In the periphery.he adrenergic system plays an important role in regulating the cardiovascular system . Increased sympathetic discharge to the heart increases the rate and force of contraction mediated through beta-1 receptors. Circulating adrenaline also acts on cardiac tissue.nd.n addition.cts both on alpha-1 adrenoceptors in arterial smooth muscle.timulating vasoconstriction.nd on beta-2 adrenoceptors in vascular beds of skeletal muscle.timulating vasodilation. In the CNS.oradrenaline is thought to be involved in the regulation of mood.nd various psychoactive drugs alter noradrenergic function. Numerous drugs exert their actions via adrenoceptors: e.g..eta-2 selective agonists such as salbutamol are used in the acute treatment of asthma.hile alpha agonists prolong the action of local anaesthetics.nd act as nasal decongestants . Adrenoceptors can be divided into three main classes based on sequence similarity.eceptor pharmacology and signalling mechanisms. Further subdivisions exist within each class. A large number of agonists and antagonists distinguish between the different classes of adrenoceptor; by contrast.elatively small differences in agonist and antagonist affinities are demonstrated.specially within the alpha-1 and alpha-2 adrenoceptor subtypes .
  IPR002233:Adrenergic receptor
IPR000276:7tm_1 
Evalue:-83.2218475341797 
Location:68-437IPR000735:ADRENRGCA2CR 
Evalue:0 
Location:29-46IPR000735:ADRENRGCA2CR 
Evalue:0 
Location:445-460
SequencesProtein: ADA2C_HUMAN (462 aa)
mRNA: NM_000683
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords)
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentK04140
  Level 3 annotation:
    adrenergic receptor, alpha 2c
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 653 residues, 3738093-3740049Exon2: 2 residues, -Jump to ADA2C_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3402 3285671-3411436 ~-126K 27271(RGS12)(+)Loci: 3403 3738093-3740049 ~-2K 27284(ADRA2C)(+)Loci: 3401 3046205-3215484 ~-169K 27267(HD)(+)Link out to UCSC