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0ADA1B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameADRA1B
DescriptionAlpha-1b adrenergic receptor (alpha 1b-adrenoceptor) (alpha 1b- adrenoreceptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004937 alpha1-adrenergic receptor activity (TAS)
0008283 cell proliferation (TAS)
0007267 cell-cell signaling (TAS)
0007275 development (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)
0007188 G-protein signaling, coupled to cAMP nucleo... (TAS)
0007243 protein kinase cascade (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In the periphery.he adrenergic system plays an important role in regulating the cardiovascular system . Increased sympathetic discharge to the heart increases the rate and force of contraction mediated through beta-1 receptors. Circulating adrenaline also acts on cardiac tissue.nd.n addition.cts both on alpha-1 adrenoceptors in arterial smooth muscle.timulating vasoconstriction.nd on beta-2 adrenoceptors in vascular beds of skeletal muscle.timulating vasodilation. In the CNS.oradrenaline is thought to be involved in the regulation of mood.nd various psychoactive drugs alter noradrenergic function. Numerous drugs exert their actions via adrenoceptors: e.g..eta-2 selective agonists such as salbutamol are used in the acute treatment of asthma.hile alpha agonists prolong the action of local anaesthetics.nd act as nasal decongestants . Adrenoceptors can be divided into three main classes based on sequence similarity.eceptor pharmacology and signalling mechanisms. Further subdivisions exist within each class. A large number of agonists and antagonists distinguish between the different classes of adrenoceptor; by contrast.elatively small differences in agonist and antagonist affinities are demonstrated.specially within the alpha-1 and alpha-2 adrenoceptor subtypes .Alpha-1B receptor mRNA is distributed widely.igh levels occurring inthe CNS (e.g..erebral cortex and brainstem) and in peripheral tissues(e.g..he kidney and lung). The receptor is coupled to the phosphoinositidepathway through a pertussis-toxin-insensitive G-protein.robably of theGq/G11 class .
  IPR001115:Adrenergic receptor, alpha-1B
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In the periphery.he adrenergic system plays an important role in regulating the cardiovascular system . Increased sympathetic discharge to the heart increases the rate and force of contraction mediated through beta-1 receptors. Circulating adrenaline also acts on cardiac tissue.nd.n addition.cts both on alpha-1 adrenoceptors in arterial smooth muscle.timulating vasoconstriction.nd on beta-2 adrenoceptors in vascular beds of skeletal muscle.timulating vasodilation. In the CNS.oradrenaline is thought to be involved in the regulation of mood.nd various psychoactive drugs alter noradrenergic function. Numerous drugs exert their actions via adrenoceptors: e.g..eta-2 selective agonists such as salbutamol are used in the acute treatment of asthma.hile alpha agonists prolong the action of local anaesthetics.nd act as nasal decongestants . Adrenoceptors can be divided into three main classes based on sequence similarity.eceptor pharmacology and signalling mechanisms. Further subdivisions exist within each class. A large number of agonists and antagonists distinguish between the different classes of adrenoceptor; by contrast.elatively small differences in agonist and antagonist affinities are demonstrated.specially within the alpha-1 and alpha-2 adrenoceptor subtypes .
  IPR002233:Adrenergic receptor
IPR000276:7tm_1 
Evalue:-101.200660705566 
Location:62-348IPR001115:ADRENRGCA1BR 
Evalue:0 
Location:24-44IPR001115:ADRENRGCA1BR 
Evalue:0 
Location:428-447IPR001115:ADRENRGCA1BR 
Evalue:0 
Location:380-399IPR001115:ADRENRGCA1BR 
Evalue:0 
Location:495-513IPR001115:ADRENRGCA1BR 
Evalue:0 
Location:4-22IPR001115:ADRENRGCA1BR 
Evalue:0 
Location:402-419IPR002233:ADRENERGICR 
Evalue:0 
Location:354-363
SequencesProtein: ADA1B_HUMAN (519 aa)
mRNA: NM_000679
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK04136
  Level 3 annotation:
    adrenergic receptor, alpha 1b
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 375 residues, 159276317-159277439Exon2: 380 residues, 159331463-159332597Exon3: 2 residues, -Jump to ADA1B_HUMAN  
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