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0ACTN4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameACTN4
DescriptionAlpha-actinin 4 (non-muscle alpha-actinin 4) (f-actin cross linking protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0015629 actin cytoskeleton (TAS)
0005737 cytoplasm (TAS)
0005634 nucleus (TAS)
0005200 structural constituent of cytoskeleton (TAS)
0006928 cell motility (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The calponin homology domain (also known as CH-domain) is a superfamily of actin-binding domains found in both cytoskeletal proteins and signal transduction proteins . It comprises the following groups of actin-binding domains:Actinin-type (including spectrin.imbrin.BP-280) (see ).Calponin-type (see ).A comprehensive review of proteins containing this type of actin-binding domains is given in .The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity . Most proteins have two copies of the CH domain.owever some proteins such as calponin and the human vav proto-oncogene () have only a single copy. The structure of an example CH-domain has recently been solved .
  IPR001715:Calponin-like actin-binding
Spectrin repeats are found in several proteins involved incytoskeletal structure. These include spectrin.lpha-actininand dystrophin. The spectrin repeat forms athree helix bundle. The second helix is interrupted by prolinein some sequences. The repeats are defined by a characteristictryptophan (W) residue at position 17 in helix A and a leucine(L) at 2 residues from the carboxyl end of helix C.
  IPR002017:Spectrin repeat
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1.... and 12; these residues are denoted by X...Y.X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).
  IPR002048:Calcium-binding EF-hand
This domain consists of a duplication of two EF-hand units.here each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
IPR001715:CH 
Evalue:-40.0087738037109 
Location:164-269IPR001715:CH 
Evalue:-32.7695503234863 
Location:51-154IPR011992:EF-Hand_type 
Evalue:-31.5528411865234 
Location:837-911IPR002017:Spectrin 
Evalue:-31.443696975708 
Location:413-518IPR002017:Spectrin 
Evalue:-20.0969104766846 
Location:649-752IPR002017:Spectrin 
Evalue:-17.9586067199707 
Location:293-403IPR002017:Spectrin 
Evalue:-16.1938209533691 
Location:528-639IPR002048:efhand 
Evalue:-3.53760194778442 
Location:769-797
SequencesProtein: ACTN4_HUMAN (911 aa)
mRNA: D89980 NM_004924
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
A dendritic spine is a mushroom-shaped bud that protrudes from a dendrite and forms one half of a synapse, especially in synapses of the cortex. The dendrites of cortical neurons typically are densely covered with such spines, which enable single cells to receive input from thousands of others.
sdb:0134 dendritic spine  (Evidence:keywords)
cytoskeleton filaments is one kind of structural components to maintain synapse morphology and bear the related function which is connected with the synaptic morphology.
sdb:0280 cytoskeletal filaments  (Evidence:keywords)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentK05699
  Level 3 annotation:
    actinin, alpha
  Level 2 annotation:
    Regulation of actin cytoskeleton
    Focal adhesion
    Adherens junction
    Tight junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 74 residues, 43830166-43830387Exon2: 40 residues, 43883079-43883194Exon3: 42 residues, 43883481-43883601Exon4: 31 residues, 43887413-43887500Exon5: 31 residues, 43888523-43888611Exon6: 28 residues, 43890596-43890675Exon7: 29 residues, 43891874-43891956Exon8: 30 residues, 43892736-43892822Exon9: 33 residues, 43896948-43897041Exon10: 79 residues, 43899565-43899796Exon11: 51 residues, 43900406-43900554Exon12: 52 residues, 43904017-43904168Exon13: 38 residues, 43906093-43906202Exon14: 49 residues, 43906416-43906557Exon15: 63 residues, 43906636-43906819Exon16: 47 residues, 43906910-43907045Exon17: 62 residues, 43908203-43908383Exon18: 51 residues, 43909436-43909583Exon19: 29 residues, 43910425-43910506Exon20: 55 residues, 43911475-43911634Exon21: 421 residues, 43911753-43913010Exon22: 2 residues, -Jump to ACTN4_HUMANExon1: 52 residues, 43830233-43830387Exon2: 40 residues, 43883079-43883194Exon3: 42 residues, 43883481-43883601Exon4: 31 residues, 43887413-43887500Exon5: 31 residues, 43888523-43888611Exon6: 28 residues, 43890596-43890675Exon7: 29 residues, 43891874-43891956Exon8: 30 residues, 43892736-43892822Exon9: 33 residues, 43896948-43897041Exon10: 79 residues, 43899565-43899796Exon11: 51 residues, 43900406-43900554Exon12: 52 residues, 43904017-43904168Exon13: 38 residues, 43906093-43906202Exon14: 49 residues, 43906416-43906557Exon15: 63 residues, 43906636-43906819Exon16: 47 residues, 43906910-43907045Exon17: 62 residues, 43908203-43908383Exon18: 51 residues, 43909436-43909583Exon19: 29 residues, 43910425-43910506Exon20: 55 residues, 43911475-43911634Exon21: 98 residues, 43911753-43912041Exon22: 2 residues, -Jump to ACTN4_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3108 43830166-43913010 ~-83K 18756(ACTN4)(+)Loci: 4387 43953451-43955988 ~-3K 18760(LGALS7)(-)Loci: 3109 43971693-43974232 ~-3K 18761(LGALS7)(+)Loci: 4388 44061041-44082201 ~-21K 18769(SIRT2)(-)Loci: 3110 44082454-44091373 ~-9K 18775(NFKBIB)(+)Loci: 4389 44097746-44113376 ~-16K 18777(SARS2)(-)Loci: 3111 44113187-44115497 ~-2K 18779(MRPS12)(+)Loci: 3112 44308259-44361886 ~-54K 18787(PAK4)(+)Loci: 3107 43616179-43770042 ~-154K 18750(RYR1)(+)Link out to UCSC