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0ACTH_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionActin, gamma-enteric smooth muscle (smooth muscle gamma actin) (alpha- actin-3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Actin .s a ubiquitous protein involved in the formation of filamentsthat are major components of the cytoskeleton. These filaments interact with myosin to produce a sliding effect.hich is the basis of muscularcontraction and many aspects of cell motility.ncluding cytokinesis. Eachactin protomer binds one molecule of ATP and has one high affinity site foreither calcium or magnesium ions.s well as several low affinity sites.Actin exists as a monomer in low salt concentrations.ut filaments formrapidly as salt concentration rises.ith the consequent hydrolysis of ATP.Actin from many sources forms a tight complex with deoxyribonuclease(DNase I) although the significance of this is still unknown. The formationof this complex results in the inhibition of DNase I activity.nd actinloses its ability to polymerise. It has been shown that an ATPase domainof actin shares similarity with ATPase domains of hexokinase and hsp70proteins .In vertebrates there are three groups of actin isoforms: alpha.eta and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exists in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming.ell shape determination.ip growth.raviperception.ell wall some divergent actin-like proteins have been identified in several species. These proteins include centractin (actin-RPV) from mammals.ungi yeast ACT5.eurospora crassa ro-4) and Pneumocystis carinii.hich seems to be a component of a multi-subunit centrosomal complex involved in microtubule based vesicle motility (this subfamily is known as ARP1); ARP2 subfamily.hich includes chicken ACTL.accharomyces cerevisiae ACT2.rosophila melanogaster 14D and Caenorhabditis elegans actC; ARP3 subfamily.hich includes actin 2 from mammals.rosophila 66B.east ACT4 and Schizosaccharomyces pombe act2; and ARP4 subfamily.hich includes yeast ACT3 and Drosophila 13E.
SequencesProtein: ACTH_HUMAN (376 aa)
mRNA: NM_001615
Local Annotation
Synapse Ontology
actin exists in two states within the cell: as polymerized two-stranded helical filaments (F-actin) or as monomers (Gactin), which provide the building blocks for filament assembly.
sdb:0283 G-actin  (Evidence:keywords)
KO assignmentK05692
  Level 3 annotation:
    actin, beta/gamma, cytoplasmic
  Level 2 annotation:
    Regulation of actin cytoskeleton
    Focal adhesion
    Adherens junction
    Tight junction
    Leukocyte transendothelial migration
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 29 residues, 73973600-73973686Exon2: 56 residues, 73981910-73982072Exon3: 45 residues, 73982994-73983123Exon4: 39 residues, 73989307-73989418Exon5: 30 residues, 73989689-73989774Exon6: 56 residues, 73994119-73994281Exon7: 66 residues, 73995314-73995506Exon8: 62 residues, 73997218-73997400Exon9: 75 residues, 74000066-74000287Exon10: 2 residues, -Jump to ACTH_HUMAN  
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Loci Cluster (Details)Loci: 3171 73973600-74000287 ~-27K 20655(ACTG2)(+)Loci: 3172 74007460-74039594 ~-32K 20656(DGUOK)(+)Loci: 4449 74441789-74461472 ~-20K 20675(DCTN1)(-)Loci: 4450 74613453-74634593 ~-21K 20704(LOXL3)(-)Loci: 3170 73909654-73943518 ~-34K 20654(STAMBP)(+)Link out to UCSC