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0ACTG_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameACTG1
DescriptionActin, cytoplasmic 2 (gamma-actin).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Actin .s a ubiquitous protein involved in the formation of filamentsthat are major components of the cytoskeleton. These filaments interact with myosin to produce a sliding effect.hich is the basis of muscularcontraction and many aspects of cell motility.ncluding cytokinesis. Eachactin protomer binds one molecule of ATP and has one high affinity site foreither calcium or magnesium ions.s well as several low affinity sites.Actin exists as a monomer in low salt concentrations.ut filaments formrapidly as salt concentration rises.ith the consequent hydrolysis of ATP.Actin from many sources forms a tight complex with deoxyribonuclease(DNase I) although the significance of this is still unknown. The formationof this complex results in the inhibition of DNase I activity.nd actinloses its ability to polymerise. It has been shown that an ATPase domainof actin shares similarity with ATPase domains of hexokinase and hsp70proteins .In vertebrates there are three groups of actin isoforms: alpha.eta and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exists in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming.ell shape determination.ip growth.raviperception.ell wall deposition.tc.Recently some divergent actin-like proteins have been identified in several species. These proteins include centractin (actin-RPV) from mammals.ungi yeast ACT5.eurospora crassa ro-4) and Pneumocystis carinii.hich seems to be a component of a multi-subunit centrosomal complex involved in microtubule based vesicle motility (this subfamily is known as ARP1); ARP2 subfamily.hich includes chicken ACTL.accharomyces cerevisiae ACT2.rosophila melanogaster 14D and Caenorhabditis elegans actC; ARP3 subfamily.hich includes actin 2 from mammals.rosophila 66B.east ACT4 and Schizosaccharomyces pombe act2; and ARP4 subfamily.hich includes yeast ACT3 and Drosophila 13E.
  IPR004000:Actin/actin-like
IPR004000:Actin 
Evalue:-258.267608642578 
Location:2-375
SequencesProtein: ACTG_HUMAN (375 aa)
mRNA: NM_001614
Local Annotation
Synapse Ontology
actin exists in two states within the cell: as polymerized two-stranded helical filaments (F-actin) or as monomers (Gactin), which provide the building blocks for filament assembly.
sdb:0283 G-actin  (Evidence:keywords)
KO assignmentK05692
  Level 3 annotation:
    actin, beta/gamma, cytoplasmic
  Level 2 annotation:
    Regulation of actin cytoskeleton
    Focal adhesion
    Adherens junction
    Tight junction
    Leukocyte transendothelial migration
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 288 residues, 77091593-77092454Exon2: 62 residues, 77092547-77092729Exon3: 148 residues, 77092808-77093247Exon4: 82 residues, 77093523-77093763Exon5: 45 residues, 77093852-77093981Exon6: 24 residues, 77094354-77094422Exon7: 2 residues, -Jump to ACTG_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4323 76816673-76827450 ~-11K 16811(-)Loci: 4324 77091593-77094422 ~-3K 16823(ACTG1)(-)Loci: 3047 77261424-77279550 ~-18K 16838(HGS)(+)Loci: 3048 77451912-77454066 ~-2K 16852(NPB)(+)Loci: 3049 77603051-77608635 ~-6K 16881(GPS1)(+)Loci: 4325 77629503-77649395 ~-20K 16888(FASN)(-)Loci: 4326 77795530-77824862 ~-29K 16893(CSNK1D)(-)Loci: 4327 78208237-78249802 ~-42K 16919(RAB40B)(-)Loci: 3046 76623556-76705827 ~-82K 16801(BAIAP2)(+)Link out to UCSC