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0ACSL6_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameACSL6
DescriptionLong-chain-fatty-acid--coa ligase 6 (ec 6.2.1.3) (long-chain acyl-coa synthetase 6) (lacs 6).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005792 microsome (NAS)
0005741 mitochondrial outer membrane (NAS)
0005778 peroxisomal membrane (NAS)
0005886 plasma membrane (NAS)
0004467 long-chain-fatty-acid-CoA ligase activity (NAS)
0006637 acyl-CoA metabolism (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of prokaryotic and eukaryotic enzymes.hich appear to act via an ATP-dependent covalent binding of AMP to their substrate.hare a region of sequence similarity . This region is a Ser/Thr/Gly-rich domain that is further characterised by a conserved Pro-Lys-Gly triplet. The family of enzymes includes luciferase.ong chain fatty acid Co-A ligase.cetyl-CoA synthetase and various other closely-related synthetases.
  IPR000873:AMP-dependent synthetase and ligase
IPR000873:AMP-binding 
Evalue:-56.0757217407227 
Location:428-588IPR000873:AMP-binding 
Evalue:-41.4814872741699 
Location:122-390
SequencesProtein: ACSL6_HUMAN (697 aa)
mRNA: AF129166 NM_015256
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01897
  Level 3 annotation:
    long-chain fatty-acid-CoA ligase
  Level 2 annotation:
    Fatty acid metabolism
    Adipocytokine signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 305 residues, 131317050-131317963Exon2: 26 residues, 131323127-131323199Exon3: 36 residues, 131324111-131324213Exon4: 50 residues, 131326126-131326270Exon5: 41 residues, 131330007-131330124Exon6: 31 residues, 131331531-131331620Exon7: 26 residues, 131333719-131333792Exon8: 34 residues, 131335141-131335237Exon9: 47 residues, 131336315-131336450Exon10: 47 residues, 131336857-131336992Exon11: 28 residues, 131338349-131338427Exon12: 26 residues, 131340239-131340313Exon13: 19 residues, 131348998-131349050Exon14: 13 residues, 131350413-131350446Exon15: 61 residues, 131351639-131351818Exon16: 35 residues, 131352396-131352496Exon17: 36 residues, 131352998-131353100Exon18: 23 residues, 131353691-131353756Exon19: 40 residues, 131354444-131354559Exon20: 75 residues, 131357622-131357843Exon21: 52 residues, 131375096-131375248Exon22: 2 residues, -Jump to ACSL6_HUMANExon1: 152 residues, 131317510-131317963Exon2: 26 residues, 131323127-131323199Exon3: 36 residues, 131324111-131324213Exon4: 50 residues, 131326126-131326270Exon5: 41 residues, 131330007-131330124Exon6: 31 residues, 131331531-131331620Exon7: 26 residues, 131333719-131333792Exon8: 34 residues, 131335141-131335237Exon9: 47 residues, 131336315-131336450Exon10: 47 residues, 131336857-131336992Exon11: 28 residues, 131338349-131338427Exon12: 26 residues, 131340239-131340313Exon13: 19 residues, 131348998-131349050Exon14: 13 residues, 131350413-131350446Exon15: 61 residues, 131351639-131351818Exon16: 35 residues, 131352396-131352496Exon17: 36 residues, 131352998-131353100Exon18: 23 residues, 131353691-131353756Exon19: 40 residues, 131354444-131354559Exon20: 76 residues, 131357622-131357845Exon21: 2 residues, -Jump to ACSL6_HUMAN  
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