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0ACSL5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameACSL5
DescriptionLong-chain-fatty-acid--coa ligase 5 (ec 6.2.1.3) (long-chain acyl-coa synthetase 5) (lacs 5).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of prokaryotic and eukaryotic enzymes.hich appear to act via an ATP-dependent covalent binding of AMP to their substrate.hare a region of sequence similarity . This region is a Ser/Thr/Gly-rich domain that is further characterised by a conserved Pro-Lys-Gly triplet. The family of enzymes includes luciferase.ong chain fatty acid Co-A ligase.cetyl-CoA synthetase and various other closely-related synthetases.
  IPR000873:AMP-dependent synthetase and ligase
IPR000873:AMP-binding 
Evalue:-55 
Location:412-573IPR000873:AMP-binding 
Evalue:-45.5086364746094 
Location:107-375
SequencesProtein: ACSL5_HUMAN (683 aa)
mRNA: NM_016234 NM_203380
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01897
  Level 3 annotation:
    long-chain fatty-acid-CoA ligase
  Level 2 annotation:
    Fatty acid metabolism
    Adipocytokine signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 93 residues, 114125012-114125290Exon2: 63 residues, 114144665-114144850Exon3: 38 residues, 114148648-114148757Exon4: 23 residues, 114154258-114154323Exon5: 36 residues, 114154452-114154554Exon6: 35 residues, 114158169-114158269Exon7: 61 residues, 114159254-114159433Exon8: 13 residues, 114160210-114160243Exon9: 19 residues, 114160331-114160383Exon10: 26 residues, 114161203-114161277Exon11: 28 residues, 114161649-114161727Exon12: 47 residues, 114162920-114163055Exon13: 47 residues, 114166635-114166770Exon14: 34 residues, 114167593-114167689Exon15: 26 residues, 114171340-114171413Exon16: 31 residues, 114171694-114171783Exon17: 41 residues, 114172072-114172189Exon18: 50 residues, 114175085-114175229Exon19: 36 residues, 114176005-114176107Exon20: 26 residues, 114176535-114176607Exon21: 389 residues, 114176965-114178127Exon22: 2 residues, -Jump to ACSL5_HUMANExon1: 84 residues, 114125945-114126196Exon2: 63 residues, 114144665-114144850Exon3: 38 residues, 114148648-114148757Exon4: 23 residues, 114154258-114154323Exon5: 36 residues, 114154452-114154554Exon6: 35 residues, 114158169-114158269Exon7: 61 residues, 114159254-114159433Exon8: 13 residues, 114160210-114160243Exon9: 19 residues, 114160331-114160383Exon10: 26 residues, 114161203-114161277Exon11: 28 residues, 114161649-114161727Exon12: 47 residues, 114162920-114163055Exon13: 47 residues, 114166635-114166770Exon14: 34 residues, 114167593-114167689Exon15: 26 residues, 114171340-114171413Exon16: 31 residues, 114171694-114171783Exon17: 41 residues, 114172072-114172189Exon18: 50 residues, 114175085-114175229Exon19: 36 residues, 114176005-114176107Exon20: 26 residues, 114176535-114176607Exon21: 389 residues, 114176965-114178127Exon22: 2 residues, -Jump to ACSL5_HUMAN  
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Loci Cluster (Details)Loci: 2634 114125012-114178127 ~-53K 5715(ACSL5)(+)Loci: 2635 114197005-114487522 ~-291K 5719(VTI1A)(+)Loci: 3921 113899611-113933508 ~-34K 5712(GPAM)(-)Link out to UCSC