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0ACSL1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameACSL1
DescriptionLong-chain-fatty-acid--coa ligase 1 (ec 6.2.1.3) (long-chain acyl-coa synthetase 1) (lacs 1) (palmitoyl-coa ligase 1) (long-chain fatty acid coa ligase 2) (long-chain acyl-coa synthetase 2) (lacs 2) (acyl-coa synthetase 1) (acs1) (palmitoyl-coa ligase 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004467 long-chain-fatty-acid-CoA ligase activity (TAS)
0007586 digestion (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of prokaryotic and eukaryotic enzymes.hich appear to act via an ATP-dependent covalent binding of AMP to their substrate.hare a region of sequence similarity . This region is a Ser/Thr/Gly-rich domain that is further characterised by a conserved Pro-Lys-Gly triplet. The family of enzymes includes luciferase.ong chain fatty acid Co-A ligase.cetyl-CoA synthetase and various other closely-related synthetases.
  IPR000873:AMP-dependent synthetase and ligase
IPR000873:AMP-binding 
Evalue:-56.3098030090332 
Location:410-588IPR000873:AMP-binding 
Evalue:-45.2218475341797 
Location:122-390
SequencesProtein: ACSL1_HUMAN (698 aa)
mRNA: NM_001995
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentK01897
  Level 3 annotation:
    long-chain fatty-acid-CoA ligase
  Level 2 annotation:
    Fatty acid metabolism
    Adipocytokine signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 557 residues, 185913743-185915413Exon2: 26 residues, 185915782-185915854Exon3: 36 residues, 185915966-185916068Exon4: 50 residues, 185918504-185918648Exon5: 41 residues, 185920554-185920671Exon6: 31 residues, 185921314-185921403Exon7: 26 residues, 185923000-185923073Exon8: 34 residues, 185924038-185924134Exon9: 47 residues, 185924769-185924904Exon10: 47 residues, 185926463-185926598Exon11: 28 residues, 185928546-185928624Exon12: 26 residues, 185931228-185931302Exon13: 19 residues, 185931810-185931862Exon14: 13 residues, 185931990-185932023Exon15: 61 residues, 185934631-185934810Exon16: 35 residues, 185935031-185935131Exon17: 36 residues, 185938479-185938581Exon18: 23 residues, 185942074-185942139Exon19: 40 residues, 185946764-185946879Exon20: 77 residues, 185961467-185961694Exon21: 50 residues, 185984063-185984209Exon22: 2 residues, -Jump to ACSL1_HUMAN  
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Loci Cluster (Details)Loci: 3440 186301391-186305418 ~-4K 28479(SLC25A4)(+)Loci: 4698 185913743-185984209 ~-70K 28476(ACSL1)(-)Link out to UCSC