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0ACS2L_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameACSS1
DescriptionAcetyl-coenzyme a synthetase 2-like, mitochondrial precursor (ec 6.2.1.1) (acetate--coa ligase 2) (acetyl-coa synthetase 2) (acyl- coa synthetase short-chain family member 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of prokaryotic and eukaryotic enzymes.hich appear to act via an ATP-dependent covalent binding of AMP to their substrate.hare a region of sequence similarity . This region is a Ser/Thr/Gly-rich domain that is further characterised by a conserved Pro-Lys-Gly triplet. The family of enzymes includes luciferase.ong chain fatty acid Co-A ligase.cetyl-CoA synthetase and various other closely-related synthetases.
  IPR000873:AMP-dependent synthetase and ligase
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme) is a ubiquitous enzyme.ound in both prokaryotes and eukaryotes.hich catalyses the formation of acetyl-CoA from acetate.oenzyme A (CoA) and ATP as shown below :ATP + acetate + CoA = AMP + diphosphate + acetyl-CoAThe activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA. key intermediate in many important biosynthetic and catabolic processes. It is especially important in eukayotic species as it is the only route for the activation of acetate to acetyl-CoA in these organisms (some prokaryotic species can also activate acetate by either acetate kinase/phosphotransacetylase or by ADP-forming acetyl-CoA synthase). Eukaryotes typically have two isoforms of acetyl-CoA synthase. cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.The crystal structures of a eukaryotic (.rom yeast) and bacterial (.rom Salmonella) form of this enzyme have been determined . The yeast enzyme is trimeric.hile the bacterial enzyme is monomeric. The trimeric state of the yeast protein may be unique to this organism however.s the residues involved in the trimer interface are poorly conserved in other sequences. Despite differences in the oligomeric state of the two enzyme.he structures of the monomers are almost identical. A large N-terminal domain (~ 500 residues) containing two parallel beta sheets is followed by a small (~ 110 residues) C-terminal domain containing a three-stranded beta sheet with helices. The active site occurs at the domain interface.ith its contents determining the orientation of the C-terminal domain.
  IPR011904:Acetate--CoA ligase
IPR000873:AMP-binding 
Evalue:-122.920822143555 
Location:142-580
SequencesProtein: ACS2L_HUMAN (689 aa)
mRNA: BC044588 NM_032501
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01895
  Level 3 annotation:
    acetyl-CoA synthetase
  Level 2 annotation:
    Glycolysis / Gluconeogenesis
    Pyruvate metabolism
    Propanoate metabolism
    Reductive carboxylate cycle (CO2 fixation)
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 571 residues, 24934867-24936577Exon2: 41 residues, 24937905-24938024Exon3: 23 residues, 24941236-24941300Exon4: 44 residues, 24941447-24941575Exon5: 44 residues, 24942171-24942298Exon6: 37 residues, 24942596-24942703Exon7: 33 residues, 24943773-24943866Exon8: 48 residues, 24948645-24948783Exon9: 51 residues, 24950024-24950172Exon10: 53 residues, 24951575-24951728Exon11: 60 residues, 24952101-24952277Exon12: 68 residues, 24959394-24959594Exon13: 34 residues, 24976720-24976817Exon14: 115 residues, 24986404-24986743Exon15: 2 residues, -Jump to ACS2L_HUMANExon1: 569 residues, 24934873-24936577Exon2: 41 residues, 24937905-24938024Exon3: 23 residues, 24941236-24941300Exon4: 44 residues, 24941447-24941575Exon5: 44 residues, 24942171-24942298Exon6: 39 residues, 24942596-24942709Exon7: 33 residues, 24943773-24943866Exon8: 48 residues, 24948645-24948783Exon9: 51 residues, 24950024-24950172Exon10: 53 residues, 24951575-24951728Exon11: 60 residues, 24952101-24952277Exon12: 68 residues, 24959394-24959594Exon13: 34 residues, 24976720-24976817Exon14: 406 residues, 24986404-24987616Exon15: 2 residues, -Jump to ACS2L_HUMAN  
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